Identification of new alternative splice events in the TCIRG1 gene in different human tissues

Identification of new alternative splice events in the TCIRG1 gene in different human tissues

Autor Smirnova, A. S. Google Scholar
Morgun, A. Google Scholar
Shulzhenko, N. Google Scholar
Silva, IDCG Google Scholar
Gerbase-DeLima, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Two transcript variants (TV) of the T cell immune regulator gene 1 (TCIRG1) have already been characterized. TV1 encodes a subunit of the osteoclast vacuolar proton pump and TV2 encodes a T cell inhibitory receptor. Based on the search in dbEST, we validated by RT-PCR six new alternative splice events in TCIRG1 in most of the 28 human tissues studied. in addition, we observed that transcripts using the TV1 transcription start site and two splice forms previously described in a patient with infantile malignant osteopetrosis are also expressed in various tissues of healthy individuals. Studies of these nine splice forms in cytoplasmic RNA of peripheral blood mononuclear cells showed that at least six of them could be efficiently exported from the nucleus. Since various products with nearly ubiquitous tissue distribution are generated from TCIRG1, this gene may be involved in other processes besides immune response and bone resorption. (c) 2005 Elsevier Inc. All rights reserved.
Assunto TCIRG1
alternative splicing
splice variants
cytoplasmic RNA
RNA degradation
Idioma Inglês
Data 2005-05-13
Publicado em Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 330, n. 3, p. 943-949, 2005.
ISSN 0006-291X (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 943-949
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228427200045

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