DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions: Study in high-risk population with biopsy-based confirmation

DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions: Study in high-risk population with biopsy-based confirmation

Autor Longatto, A. Google Scholar
Pereira, SMM Google Scholar
Di Loreta, C. Google Scholar
Utagawa, M. L. Google Scholar
Makabe, S. Google Scholar
Maeda, MYS Google Scholar
Marques, J. A. Google Scholar
Santoro, CLF Google Scholar
Castelo, A. Google Scholar
Instituição Adolfo Lutz Inst
Univ Minho
Perola Byignton Hosp
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective. To compare the performances of Papanicolaou test (PapTest) and of a new liquid-based cytology method, DNA-Citoliq((R)), System (DCS), in a high-risk population, with histology confirmation.Methods. Paired specimens of exfoliated cervical cells were collected under split-sample protocol. All patients were submitted to colposcopy and a biopsy taken when any atypical transfomiation zone was seen. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both conventional and DCS methods were computed in relation to histology.Results. A total of 1095 patients were analyzed by two cytology methods and, in 425 (38.8%), histologically. There were significantly more adequate samples with DCS (98.63%) than with conventional (89.6%) smears (P < 0.001). ASCUS was diagnosed significantly more with DCS than with conventional Pap (P < 0.001). Conventional Pap misclassified as normal 55.4% (158/285) of cases with either LSIL or HSIL or cancer at histology, whereas DCS misclassified 31.2% (89/285) of cases (P < 0.001). DCS had a significantly higher sensitivity (70% and 91.3%) than the conventional Pap (49.8% and 72.8%) to detect both LSIL+ and HSIL+ at histology, respectively. On the other hand, specificity of conventional smear (88.2% and 85.2%) was significantly higher than DCS (75.4% and 70.9%) considering both LSIL+ and HSIL+ at histology, respectively.Conclusions. This study confirms the superiority of the liquid-based cylology system DCS to detect cervical lesions. the rate of adequate DSC slides was significantly higher than with conventional cytology. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave DCS system
liquid-based cytology
Papanicolaou test
cervical cancer
cervical screening
Idioma Inglês
Data de publicação 2005-05-01
Publicado em Gynecologic Oncology. San Diego: Academic Press Inc Elsevier Science, v. 97, n. 2, p. 497-500, 2005.
ISSN 0090-8258 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 497-500
Fonte http://dx.doi.org/10.1016/j.ygyno.2005.01.013
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000229231000029
Endereço permanente http://repositorio.unifesp.br/handle/11600/28285

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