Effects of the combination of bimatoprost and latanoprost on intraocular pressure in primary open angle glaucoma: a randomised clinical trial

Effects of the combination of bimatoprost and latanoprost on intraocular pressure in primary open angle glaucoma: a randomised clinical trial

Autor Doi, Larissa Morimoto Autor UNIFESP Google Scholar
Melo, LAS Google Scholar
Prata Junior, João Antonio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fac Med Triangulo Mineiro
Resumo Aims: To evaluate the effect of the combination of bimatoprost and latanoprost on intraocular pressure (IOP) in primary open angle glaucoma (POAG).Methods: An open label randomised clinical trial was conducted, which included 18 glaucomatous patients (36 eyes). in the first 4 weeks, latanoprost 0.005% was prescribed for both eyes of the patients and any other antiglaucoma medication was discontinued. in the next 4 weeks (phase 1), bimatoprost 0.03% was combined with latanoprost in one randomly assigned eye (case eye) of each patient. in the next 4 weeks (phase 2), bimatoprost was discontinued in the case eyes, while bimatoprost was substituted for latanoprost in the fellow eye (control eye). the IOP was measured at the end of the first 4 weeks (baseline measurement) and weekly during phases 1 and 2.Results: in the case eyes, the mean IOP increased along the first phase (1.8 mmHg; p = 0.006) when compared to baseline measurements. the IOP returned to previous values after discontinuation of bimatoprost in phase 2. in the control eyes, the mean IOP did not change throughout the study.Conclusion: the combination of bimatoprost and latanoprost in POAG increases the IOP and should not be considered as a therapeutic option.
Idioma Inglês
Data de publicação 2005-05-01
Publicado em British Journal of Ophthalmology. London: B M J Publishing Group, v. 89, n. 5, p. 547-549, 2005.
ISSN 0007-1161 (Sherpa/Romeo, fator de impacto)
Publicador B M J Publishing Group
Extensão 547-549
Fonte http://dx.doi.org/10.1136/bjo.2004.053074
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228444600011
Endereço permanente http://repositorio.unifesp.br/handle/11600/28267

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