Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

Autor Coplan, P. M. Google Scholar
Gupta, S. B. Google Scholar
Dubey, S. A. Google Scholar
Pitisuttithum, P. Google Scholar
Nikas, A. Google Scholar
Mbewe, B. Google Scholar
Vardas, E. Google Scholar
Schechter, M. Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
Freed, D. C. Google Scholar
Fu, T. M. Google Scholar
Mast, C. T. Google Scholar
Puthavathana, P. Google Scholar
Kublin, J. Google Scholar
Collins, K. B. Google Scholar
Chisi, J. Google Scholar
Pendame, R. Google Scholar
Thaler, S. J. Google Scholar
Gray, G. Google Scholar
Mcintyre, J. Google Scholar
Straus, W. L. Google Scholar
Condra, J. H. Google Scholar
Mehrotra, D. V. Google Scholar
Guess, H. A. Google Scholar
Emini, E. A. Google Scholar
Shiver, J. W. Google Scholar
Instituição Merck Res Labs
Mahidol Univ
Malawi Coll Med
Minist Populat & Hlth
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Univ Witwatersrand
Resumo Background. the genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades.Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-gamma enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous ( infecting) clades of HIV-1.Results. Cellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade reactivity of cellular immune responses to HIV-1 clade A, B, and C proteins was substantial for Nef proteins ( ratio, 0.97 [95% confidence interval, 0.89-1.05]) and lower for Gag proteins ( ratio, 0.67 [ 95% confidence interval, 0.62-0.73]). the difference in cross-clade reactivity to Nef and Gag proteins was significant (P < .0001).Conclusions. Cross-clade reactivity of cellular immune responses can be substantial but varies by viral protein.
Idioma Inglês
Data 2005-05-01
Publicado em Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 191, n. 9, p. 1427-1434, 2005.
ISSN 0022-1899 (Sherpa/Romeo, fator de impacto)
Editor Univ Chicago Press
Extensão 1427-1434
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228128800008

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