Myocardial performance index in female rats with myocardial infarction: Relationship with ventricular function parameters by Doppler echocardiography

Myocardial performance index in female rats with myocardial infarction: Relationship with ventricular function parameters by Doppler echocardiography

Autor Cury, Alexandre Ferreira Autor UNIFESP Google Scholar
Bonilha, Andre Autor UNIFESP Google Scholar
Saraiva, Roberto Autor UNIFESP Google Scholar
Campos, Orlando Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos C Autor UNIFESP Google Scholar
De Paola, Angelo Amaro Vicenzo Autor UNIFESP Google Scholar
Fischer, Claudio Autor UNIFESP Google Scholar
Tucci, Paulo Ferreira Autor UNIFESP Google Scholar
Moises, Valdir Ambrosio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: the aim of the study was to analyze the myocardial performance index (MPI), its relationship with the standard variables of systolic and diastolic functions, and the influence of time intervals in an experimental model of female rats with myocardial infarction (MI).Methods: Forty-one Wistar female rats were submitted to surgery to induce MI. Six weeks later, Doppler echocardiography was performed to assess infarct size (IS,%), fractional area change (FAC,%), ejection fraction biplane Simpson (EF), E/A ratio of mitral inflow, MPI and its time intervals: isovolumetric contraction (IVCT, ms) and relaxation (IVRT, ms) times, and ejection time (ET, ms); MPI = IVCT + IVRT/ET.Results: EF and FAC were progressively lower in rats with small, medium and large-size MI (P < .001). E/A ratio was higher only in rats with large-size MI (6.25 ± 2.69; P < .001). MPI was not different between control rats and small-size MI (0.37 ± 0.03 vs 0.34 ± 0.06, P = .87), but different between large and medium-size MI (0.69 ± 0.08 vs 0.47 ± 0.07; P < .001) and between these two compared to small-size MI. MPI correlated with IS (r = 0.85; P < .001), EF (r = -0.86; P < .001), FAC (r = -0.77; P < .001) and E/A ratio (r = 0.77; P < .001, non-linear). IVCT was longer in large size MI compared to medium-size MI (31.87 ± 7.99 vs 15.92 ± 5.88; P < .001) and correlated with IS (r = 0.85; P < .001) and MPI (r = 0.92; P < .001). ET was shorter only in large-size MI (81.07 ± 7.23; P < .001), and correlated with IS (r = -0.70; P < .001) and MPI (r = -0.85; P < .001). IVRT was shorter only in large-size compared to medium-size MI (24.40 ± 5.38 vs 29.69 ± 5.92; P < .037), had borderline correlation with MPI (r = 0.34; P = .0534) and no correlation with IS (r = 0.26; p = 0.144).Conclusions: the MPI increased with IS, correlated inversely with systolic function parameters and had a non-linear relationship with diastolic function. These changes were due to the increase of IVCT and a decrease of ET, without significant influence of IVRT.
Idioma Inglês
Data de publicação 2005-05-01
Publicado em Journal of the American Society of Echocardiography. St Louis: Mosby, Inc, v. 18, n. 5, p. 454-460, 2005.
ISSN 0894-7317 (Sherpa/Romeo, fator de impacto)
Publicador Mosby, Inc
Extensão 454-460
Fonte http://dx.doi.org/10.1016/j.echo.2005.01.030
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228980800012
Endereço permanente http://repositorio.unifesp.br/handle/11600/28257

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