Gene expression in the salivary complexes from Haementeria depressa leech through the generation of expressed sequence tags

Gene expression in the salivary complexes from Haementeria depressa leech through the generation of expressed sequence tags

Autor Faria, F. Google Scholar
Junqueira-de-Azevedo, I. D. Google Scholar
Ho, P. L. Google Scholar
Sampaio, M. U. Google Scholar
Chudzinski-Tavassi, A. M. Google Scholar
Instituição Inst Bunantan
Inst Buntantan
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo A survey of the transcriptional profile of Haementeria depressa Ringuelet, 1972 (Annelida, Hirudinea) salivary complexes was produced through expressed sequence tag (EST). Sequences from 898 independent clones were assembled in 555 clusters, representing the transcript profile of this tissue. the repertoire of possible proteins involved in feeding and host interaction processes of the leech corresponded to 10.6% of all identified transcripts (67 clusters), being the carbonic anhydrases (30%), several coagulation inhibitors (25%) and hemerythrin-like molecules (19%), the major components. Among the 387 clusters matching cellular proteins, the majority represents molecules involved in gene and protein expression, reflecting a high specialization of this tissue for protein synthesis. Our H. depressa dbEST was also compared to those from other blood-feeding organisms, providing evidences that among the secreted proteins, the coagulation inhibitors present a profile very characteristic of this animal class. Published by Elsevier B.V.
Palavra-chave leeches
transcriptome
expressed sequence tag
blood-feeding
coagulation inhibitors
Idioma Inglês
Data de publicação 2005-04-11
Publicado em Gene. Amsterdam: Elsevier B.V., v. 349, p. 173-185, 2005.
ISSN 0378-1119 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 173-185
Fonte http://dx.doi.org/10.1016/j.gene.2004.12.022
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228757600017
Endereço permanente http://repositorio.unifesp.br/handle/11600/28248

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