Cardiovascular adaptations in rats submitted to a resistance-training model

Cardiovascular adaptations in rats submitted to a resistance-training model

Autor Barauna, V. G. Google Scholar
Junior, MLB Google Scholar
Rosa, LFBC Google Scholar
Casarini, D. E. Google Scholar
Krieger, J. E. Google Scholar
Oliveira, E. M. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo 1. the present study sought to evaluate cardiovascular adaptations, such as blood pressure (BP), heart rate (HR) and cardiac hypertrophy, to resistance training (RT) in a rat model.2. the training protocol consisted of four sets of 10-12 repetitions of the squat exercise performed at 65-75% of one repetition maximum (1RM) over 4 weeks. Animals were randomly divided into three groups: control (n=8, CO), electrically stimulated (n=8, ES) and trained (n=8, TR; also electrically stimulated). Blood pressure and HR were measured by a direct method in conscious rats after the training period.3. All groups began with similar 1RM and 1RM/bodyweight (BW) ratio, however, at the end of the protocol only the TR group was different from the beginning (56% and 50%, respectively; both P < 0.01). the CO and ES groups had similar values for cardiac chambers weight/BW ratio, HR and diastolic, systolic and mean BP. Left ventricular hypertrophy (LVH) determined by the left ventricle (LV) weight/BW ratio was increased in the TR group (12%) when compared to CO (P < 0.01) or ES groups (P < 0.01). No changes were found in the weights of the atrium or right ventricle. Diastolic (14%) and mean BP (13%) were lower in the TR group (P < 0.05), whereas systolic BP and HR remained unchanged.4. Collectively these results demonstrate that the rat RT model used is associated with significant development of cardiac hypertrophy and lowering of resting BP. These cardiovascular adaptations seem to a result of the training exercise and not influenced by stress since circulating catecholamine levels and adrenal gland weights remained unchanged in all groups.
Palavra-chave cardiovascular system
myocardial hypertrophy
resistance training
weight lifting
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Clinical and Experimental Pharmacology and Physiology. Carlton: Blackwell Publishing Asia, v. 32, n. 4, p. 249-254, 2005.
ISSN 0305-1870 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Asia
Extensão 249-254
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228049000003
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