Bone marrow features in children with HIV infection and peripheral blood cytopenias

Mostrar registro simples Meira, D. G. Lorand-Metze, I Toro, ADC Silva, MTN Vilela, MMS 2016-01-24T12:37:46Z 2016-01-24T12:37:46Z 2005-04-01
dc.identifier.citation Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 51, n. 2, p. 114-119, 2005.
dc.identifier.issn 0142-6338
dc.description.abstract HIV infection is associated with numerous abnormalities affecting both the myeloid and lymphoid lineages. We studied the features associated with peripheral cytopenias as the first sign of HIV infection in children. Peripheral blood (PB) counts, PB and bone marrow (BM) lymphocyte subsets, as well as viral load and serum levels of ferritin, vitamin B12, and folic acid were determined. Five children were naive of treatment (Group 1) and three were under HAART (Group 2). in Group 1 all patients had anemia of chronic disease. One had a bone marrow culture positive for Mycobacterium avium intracellulare and pancytopenia. Besides this, neutropenia and thrombocytopenia were seen in one patient each. in Group 2 anemia was found in all, neutropenia in one, and thrombocytopenia in two patients. Peripheral blood cytopenias were due to HAART toxicity in one patient. in the other two they were due to iron or folate deficiency. Bone marrow cytology showed cell abnormalities mainly in granulocytic precursors and megakaryocytes. All except two (taking HAART) patients had a high viral load. There was a straight correlation between viral load in PB and bone marrow. Viral load was correlated with peripheral CD4 but not with CD8 lymphocytes. A decrease in bone marrow B lymphocytes was seen in all patients. the introduction of HAART improved peripheral cytopenias. Bone marrow examination was useful for determining the etiology of the cytopenias and for detection of opportunistic infection. Hemopoietic cell abnormalities were similar to those seen in adults and indicative of HIV infection. en
dc.format.extent 114-119
dc.language.iso eng
dc.publisher Oxford Univ Press
dc.relation.ispartof Journal of Tropical Pediatrics
dc.rights Acesso restrito
dc.title Bone marrow features in children with HIV infection and peripheral blood cytopenias en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation State Univ Campinas, UNICAMP, Sch Med, Ctr Invest Pediat,Dept Pediat, BR-13083887 Campinas, SP, Brazil
dc.identifier.doi 10.1093/tropej/fmh096
dc.description.source Web of Science
dc.identifier.wos WOS:000228637800012

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