Bone marrow features in children with HIV infection and peripheral blood cytopenias

Bone marrow features in children with HIV infection and peripheral blood cytopenias

Autor Meira, D. G. Google Scholar
Lorand-Metze, I Google Scholar
Toro, ADC Google Scholar
Silva, MTN Google Scholar
Vilela, MMS Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo HIV infection is associated with numerous abnormalities affecting both the myeloid and lymphoid lineages. We studied the features associated with peripheral cytopenias as the first sign of HIV infection in children. Peripheral blood (PB) counts, PB and bone marrow (BM) lymphocyte subsets, as well as viral load and serum levels of ferritin, vitamin B12, and folic acid were determined. Five children were naive of treatment (Group 1) and three were under HAART (Group 2). in Group 1 all patients had anemia of chronic disease. One had a bone marrow culture positive for Mycobacterium avium intracellulare and pancytopenia. Besides this, neutropenia and thrombocytopenia were seen in one patient each. in Group 2 anemia was found in all, neutropenia in one, and thrombocytopenia in two patients. Peripheral blood cytopenias were due to HAART toxicity in one patient. in the other two they were due to iron or folate deficiency. Bone marrow cytology showed cell abnormalities mainly in granulocytic precursors and megakaryocytes. All except two (taking HAART) patients had a high viral load. There was a straight correlation between viral load in PB and bone marrow. Viral load was correlated with peripheral CD4 but not with CD8 lymphocytes. A decrease in bone marrow B lymphocytes was seen in all patients. the introduction of HAART improved peripheral cytopenias. Bone marrow examination was useful for determining the etiology of the cytopenias and for detection of opportunistic infection. Hemopoietic cell abnormalities were similar to those seen in adults and indicative of HIV infection.
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 51, n. 2, p. 114-119, 2005.
ISSN 0142-6338 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 114-119
Fonte http://dx.doi.org/10.1093/tropej/fmh096
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228637800012
Endereço permanente http://repositorio.unifesp.br/handle/11600/28234

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