A xylogalactofucan from the brown seaweed Spatoglossum schroederi stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells

A xylogalactofucan from the brown seaweed Spatoglossum schroederi stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells

Author Rocha, HAD Google Scholar
Bezerra, LCLD Google Scholar
Albuquerque, IRL de Google Scholar
Costa, L. S. Google Scholar
Guerra, CMP Google Scholar
Abreu, L. D. de Google Scholar
Nader, H. B. Google Scholar
Leite, E. L. Google Scholar
Institution Univ Fed Rio Grande Norte
Universidade Federal de São Paulo (UNIFESP)
Abstract The brown seaweed Spatoglossum schroederi (Dictyotaceae) contains three main fucans (fucans A, B and C) with different mobility in electrophoresis. the fucan with highest mobility (fucan C) was precipitated with 2.0 volumes of acetone, purified using a combination of ion exchange chromatography and electrophoresis. It showed an MW of 24 kDa determined by HPLC and Sephadex G-75 chromatography and migrates as a single band in three distinct electrophoretic systems. This fucan contains fucose, xylose, galactose and sulfate in a molar ratio 1 :0.6: 2:2.3. the fucan has neither anticoagulant (from 10 to 100 mu g) nor hemorrhagic activities (100 mu g/mL). in addition, fucan C is neither cytotoxic nor cytostatic. However, fucan C (100 mu g/mL) stimulated the synthesis of an antithrombotic heparan sulfate from endothelial cells of rabbit aorta. the results suggest that fucan C might be used as an antithrombotic therapeutic compound.
Language English
Date 2005-04-01
Published in Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 71, n. 4, p. 379-381, 2005.
ISSN 0032-0943 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 379-381
Origin http://dx.doi.org/10.1055/s-2005-864110
Access rights Closed access
Type Article
Web of Science ID WOS:000229254600020
URI http://repositorio.unifesp.br/handle/11600/28229

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