Effects of progesterone blockade over cocaine-induced genital reflexes of paradoxical sleep-deprived male rats

Effects of progesterone blockade over cocaine-induced genital reflexes of paradoxical sleep-deprived male rats

Autor Andersen, M. L. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Paradoxical sleep deprivation (PSD) enhances cocaine-induced genital reflexes (penile erection [PE] and ejaculation [EJ]) in male rats and induces a significant increase in progesterone concentration. As progesterone treatment facilitates PE in PSD castrated rats, we may speculate that progesterone appears to be a relevant hormonal factor eliciting genital reflexes in PSD males. in order to expand the latter finding, different doses of antiprogestin mifepristone (vehicle, 2.5, 5, 10, and 20 mg/kg, s.c.) were administered to PSD rats at the end of a 4-day period of PSD 1 h prior to cocaine administration (7 mg/kg, i.p.) and placed in observation cages for the evaluation of genital reflexes. Pretreatment with vehicle induced PE in all rats and this effect was significantly reduced by mifepristone at 5 to 20 mg/kg doses that lowered the proportion to 40% of the rats. the frequency of PE was also significantly reduced for all doses used. There were no significant differences between vehicle and mifepristone in EJ behavior. As for hormone concentrations, mifepristone reduced progesterone concentrations at the 520 mg/kg doses compared to vehicle group. At 20 mg/kg, it also elevated testosterone concentrations. in addition, mifepristone administration induced a significant decrease in the duration of PS episodes at all doses. These data suggest that progesterone exerts an essential role in erectile response induced by cocaine in PSD male rats. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave paradoxical sleep deprivation
genital reflexes
progesterone
cocaine
mifepristone
sleep
rat
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 47, n. 4, p. 477-484, 2005.
ISSN 0018-506X (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 477-484
Fonte http://dx.doi.org/10.1016/j.yhbeh.2004.12.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228004200013
Endereço permanente http://repositorio.unifesp.br/handle/11600/28221

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