cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients

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dc.contributor.author Gatti, L. L.
dc.contributor.author Souza, EKFE
dc.contributor.author Leite, K. R.
dc.contributor.author Bastos, ELD
dc.contributor.author Vicentini, L. R.
dc.contributor.author Silva, L. C. da
dc.contributor.author Smith, MDC
dc.contributor.author Payao, SLM
dc.date.accessioned 2016-01-24T12:37:45Z
dc.date.available 2016-01-24T12:37:45Z
dc.date.issued 2005-04-01
dc.identifier http://dx.doi.org/10.1016/j.diagmicrobio.2004.11.007
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 51, n. 4, p. 231-235, 2005.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28216
dc.description.abstract Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with development of peptic ulcer disease and gastric malignancies. the vacuolating cytotoxin (vacA), cagA gene, and babA2 gene are important virulence factor involving gastric diseases. Eighty-nine Helicobacter pylori-positive gastric biopsies were analyzed by polymerase chain reaction and Southern blotting for H. pylori detection and genotyping with primer pairs from each virulence gene. Fifty-three strains (59%) were common vacA genotype s1/m1, and only 14 (16%) were s2/m2, 12% of strains was found to have multiple infection. the cagA presence was detected in 48% (43 strains) and babA2 gene was detected in 44% of our H. pylori strains. We observed high percentage of s1/m2 strains with chronic gastritis and peptic ulcer and a significant correlation between cagA presence with the s1 allele and babA2 gene with chronic gastritis. (c) 2005 Elsevier Inc. All rights reserved. en
dc.format.extent 231-235
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.subject Helicobacter pylori en
dc.subject chronic gastritis en
dc.subject peptic ulcer disease en
dc.subject gastric malignancies en
dc.subject vacA en
dc.subject cagA en
dc.subject babA2 en
dc.title cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Fac Med Marilia
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Sirio Libanes
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Fac Med Marilia, FAMEMA, Homoctr, Disciplina Genet, BR-17519050 Marilia, SP, Brazil
dc.description.affiliation Fac Med Marilia, FAMEMA, Homoctr, Disciplina Biol Mol, BR-17519050 Marilia, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliation Hosp Sirio Libanes, Lab Patol Mol, BR-01308050 São Paulo, Brazil
dc.description.affiliation Fac Med Marilia, FAMEMA, Disciplina Cirurg, BR-17519050 Marilia, SP, Brazil
dc.description.affiliation Fac Med Marilia, Serv Endoscopia, BR-17519050 Marilia, SP, Brazil
dc.description.affiliation Fac Med Marilia, FAMEMA, Disciplina Patol, BR-17519050 Marilia, SP, Brazil
dc.description.affiliation Univ São Paulo Bauru, BR-17011160 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.diagmicrobio.2004.11.007
dc.description.source Web of Science
dc.identifier.wos WOS:000228648400002



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