cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients

cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients

Author Gatti, L. L. Google Scholar
Souza, EKFE Google Scholar
Leite, K. R. Google Scholar
Bastos, ELD Google Scholar
Vicentini, L. R. Google Scholar
Silva, L. C. da Google Scholar
Smith, MDC Google Scholar
Payao, SLM Google Scholar
Institution Fac Med Marilia
Universidade Federal de São Paulo (UNIFESP)
Hosp Sirio Libanes
Universidade de São Paulo (USP)
Abstract Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with development of peptic ulcer disease and gastric malignancies. the vacuolating cytotoxin (vacA), cagA gene, and babA2 gene are important virulence factor involving gastric diseases. Eighty-nine Helicobacter pylori-positive gastric biopsies were analyzed by polymerase chain reaction and Southern blotting for H. pylori detection and genotyping with primer pairs from each virulence gene. Fifty-three strains (59%) were common vacA genotype s1/m1, and only 14 (16%) were s2/m2, 12% of strains was found to have multiple infection. the cagA presence was detected in 48% (43 strains) and babA2 gene was detected in 44% of our H. pylori strains. We observed high percentage of s1/m2 strains with chronic gastritis and peptic ulcer and a significant correlation between cagA presence with the s1 allele and babA2 gene with chronic gastritis. (c) 2005 Elsevier Inc. All rights reserved.
Keywords Helicobacter pylori
chronic gastritis
peptic ulcer disease
gastric malignancies
vacA
cagA
babA2
Language English
Date 2005-04-01
Published in Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 51, n. 4, p. 231-235, 2005.
ISSN 0732-8893 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 231-235
Origin http://dx.doi.org/10.1016/j.diagmicrobio.2004.11.007
Access rights Closed access
Type Article
Web of Science ID WOS:000228648400002
URI http://repositorio.unifesp.br/handle/11600/28216

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