Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats

Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats

Autor Wohlers, Marta Google Scholar
Navarro Xavier, Roberta Araujo Google Scholar
Oyama, Lila Missae Google Scholar
Ribeiro, Eliane Beraldi Google Scholar
Oller do Nascimento, Claudia Maria Google Scholar
Casarini, Dulce Elena Google Scholar
Flor Silveira, Vera Lucia Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We have previously demonstrated that both n-3 and n-6 polyunsaturated fatty acids (PUFA)-rich diets decrease the acute inflammatory response partially explained by the high corticosterone basal levels. the present study aimed to determine the effect of hyperlipidic diets (PUFA n-3 or n-6) on phagocytosis, hydrogen peroxide (H2O2) and nitric oxide (NO) release by macrophages, bradykinin (BK) and NO release in the paw inflammatory perfusate and Kallikrein (KK), corticosterone and leptin blood levels. Hyperlipidic diets decreased H2O2 release from macrophages stimulated by carrageenan or phorbol-miristate-acetate (PMA), NO release from macrophage stimulated by carrageenan, BK and NO release in the edema perfusate, KK plasma levels and the increase of serum leptin after carrageenan stimulus. These data show that both fish and soybean oil-rich diets promote similar alterations on inflammatory mediators of carrageenan edema and a causal association with the anti-inflammatory effect of these diets.
Palavra-chave polyunsaturated fatty acids
inflammation
corticosterone
bradykinin
nitric oxide
hydrogen peroxide
leptin
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Inflammation. New York: Springer/plenum Publishers, v. 29, n. 2-3, p. 81-89, 2005.
ISSN 0360-3997 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 81-89
Fonte http://dx.doi.org/10.1007/s10753-006-9002-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000240258300003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28215

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