Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations

Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations

Autor Garcia, Simone Google Scholar
Ramos, Carolina O. Google Scholar
Senra, Juliana FV Google Scholar
Vilas-Boas, Fabio Google Scholar
Rodrigues, Maurício M. Autor UNIFESP Google Scholar
Campos-De-Carvalho, Antonio C. Google Scholar
Ribeiro-Dos-Santos, Ricardo Google Scholar
Soares, Milena BP Google Scholar
Instituição Fundacao Oswaldo Cruz
Universidade Federal do Rio de Janeiro (UFRJ)
Hosp Santa Izabel
Universidade Federal de São Paulo (UNIFESP)
Resumo Chagas' disease, caused by Trypanosoma cruzi infection, is one of the main causes of death due to heart failure in Latin American countries. Benznidazole, the chemotherapeutic agent most often used for the treatment of chagasic patients, is highly toxic and has limited efficacy, especially in the chronic phase of the disease. in the present study we used a mouse model of chronic Chagas' disease to investigate the effects of benznidazole treatment during the chronic phase on disease progression. the hearts of benznidazole-treated mice had decreased parasitism and myocarditis compared to the hearts of untreated chagasic mice. Both groups of Trypanosoma cruzi-infected mice had significant alterations in their electrocardiograms compared to those of the healthy mice. However, untreated mice had significantly higher cardiac conduction disturbances than benznidazole-treated mice, including intraventricular conduction disturbances, atrioventricular blocks, and extrasystoles. the levels of antibodies against T. cruzi antigens (epimastigote extract, P-2 beta, and trans-sialidase) as well as antibodies against peptides of the second extracellular loops beta(1)-adrenergic and M-2-muscarinic cardiac receptors were also lower in the sera from benznidazole-treated mice than in the sera from untreated mice. These results demonstrate that treatment with benznidazole in the chronic phase of infection prevents the development of severe chronic cardiomyopathy, despite the lack of complete parasite eradication. in addition, our data highlight the role of parasite persistence in the development of chronic Chagas' disease and reinforce the importance of T. cruzi elimination in order to decrease or prevent the development of severe chagasic cardiomyopathy.
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 49, n. 4, p. 1521-1528, 2005.
ISSN 0066-4804 (Sherpa/Romeo, fator de impacto)
Publicador Amer Soc Microbiology
Extensão 1521-1528
Fonte http://dx.doi.org/10.1128/AAC.49.4.1521-1528.2005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228082500038
Endereço permanente http://repositorio.unifesp.br/handle/11600/28205

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