High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits

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dc.contributor.author Pomaro, D. R.
dc.contributor.author Ihara, SSM
dc.contributor.author Pinto, Leonor do Espírito Santo de Almeida [UNIFESP]
dc.contributor.author Ueda, Ivete [UNIFESP]
dc.contributor.author Casarini, Dulce E. [UNIFESP]
dc.contributor.author Ebihara, Fabiana [UNIFESP]
dc.contributor.author Santos, Andreza O. [UNIFESP]
dc.contributor.author Izar, Maria Cristina de Oliveira [UNIFESP]
dc.contributor.author Fonseca, Francisco Antonio Helfenstein [UNIFESP]
dc.date.accessioned 2016-01-24T12:37:44Z
dc.date.available 2016-01-24T12:37:44Z
dc.date.issued 2005-04-01
dc.identifier http://dx.doi.org/10.1097/01.fjc.0000155384.64350.45
dc.identifier.citation Journal of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 45, n. 4, p. 295-300, 2005.
dc.identifier.issn 0160-2446
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28200
dc.description.abstract Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups (>= 250 mg/dL or < 250 mg/dL). Each group was randomly assigned to receive or not quinapril (30 mg/d) added to a 0.5% cholesterol-enriched diet. Animals with high glucose levels at 1 week and that remained high after 12 weeks presented higher triglyceride levels (P < 0.02 versus basal). Those initially hyperglycemic but presenting < 250 mg/dL glucose at the end of study formed an additional group. Plasma ACE activity was lower in quinapril-treated animals (P < 0.01 versus untreated groups). However, aorta intima/media ratio and intima area were lower only in the subgroups of quinapril-treated animals with low glucose levels (P < 0.05). Our results support the hypothesis that high plasma glucose may abolish the anti atheroscl erotic effect of ACE inhibitors. en
dc.format.extent 295-300
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal of Cardiovascular Pharmacology
dc.rights Acesso aberto
dc.subject ACE inhibitor en
dc.subject atherosclerosis en
dc.subject diabetes en
dc.subject cholesterol en
dc.subject rabbits en
dc.title High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Cardiol, Dept Med, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Cardiol, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.identifier.doi 10.1097/01.fjc.0000155384.64350.45
dc.description.source Web of Science
dc.identifier.wos WOS:000227939100004



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