Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate

Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate

Autor Royes, LFF Google Scholar
Fighera, M. R. Google Scholar
Furian, A. F. Google Scholar
Oliveira, M. S. Google Scholar
Fiorenza, N. G. Google Scholar
Myskiw, J. D. Google Scholar
Frussa, R. Google Scholar
Mello, C. F. Google Scholar
Instituição Universidade Federal de Sergipe (UFS)
Universidade Federal de São Paulo (UNIFESP)
Resumo Acute intrastriatal administration of methylmalonic acid (MMA) induces convulsions through NMDA receptor-mediated mechanisms and increases production of end products of oxidative damage. Although it has been demonstrated that nitric oxide (NO) production increases with NMDA receptor stimulation and contributes to the oxidative damage observed in several neurodegenerative disorders, the role of NO in MMA-induced convulsions has not been investigated to date. in the present study we investigated the effects of the intrastriatal injection of N-omega-nitro-L-arginine methyl ester (L-NAME: 10(-4) to 100 nmol/0.5 mul) on the convulsions and striatal protein carbonylation induced by the intrastriatal injection of MMA (4.5 mumol/1.5 mul). L-NAME (10(-3) to 10(-1) nmol) protected against MMA-induced convulsions and protein carbonylation ex vivo. These results suggest the involvement of NO in the convulsive behavior and protein carbonylation elicited by MMA. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave convulsion
protein carbonylation
L-methylmalonic acid
nitric oxide
methylmalonic acidemia
L-NAME
Idioma Inglês
Data de publicação 2005-03-11
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 376, n. 2, p. 116-120, 2005.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 116-120
Fonte http://dx.doi.org/10.1016/j.neulet.2004.11.038
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227209100010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28195

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta