Learning deficits induced by sleep deprivation and recovery are not associated with altered [H-3]muscimol and [H-3]flunitrazepam binding

Learning deficits induced by sleep deprivation and recovery are not associated with altered [H-3]muscimol and [H-3]flunitrazepam binding

Autor Dubiela, Francisco Paulino Autor UNIFESP Google Scholar
Oliveira, MGM Google Scholar
Moreira, K. M. Google Scholar
Nobrega, J. N. Google Scholar
Tufik, S. Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Ctr Addict & Mental Hlth
Resumo Several studies have shown that sleep deprivation produces deficits in learning tasks, but mechanisms underlying these effects remain unclear. Other lines of evidence indicate an involvement of brain GABA systems in cognitive processes. Here, we investigated the possibility that alterations in GABA(A) or benzodiazepine (BDZ) receptor binding might underlie avoidance deficits induced by sleep deprivation. Rats were deprived of sleep for 96 h using the platform method and then trained in a step-through inhibitory avoidance task, or allowed to recover sleep for 24 h before training (sleep rebound group). Thirty minutes after training, animals were given a retention test. Both sleep-deprived and sleep-recovered animals showed a significant impairment in avoidance responding compared to cage controls, and the sleep-deprived group performed significant worse than the sleep-recovered group. A separate group of animals was sacrificed either immediately after 96 h of sleep deprivation or after 96 h of sleep deprivation followed by 24 h of sleep recovery. [H-3]muscimol and [H-3]flunitrazepam binding were examined by quantitative autoradiography in 42 brain regions, including areas involved in cognitive processes. No significant differences among groups were found in any brain region, except for a reduction in [H-3]flunitrazepam binding in the frontal cortex of sleep-recovered animals. These results confirm the deleterious effects of sleep loss on inhibitory avoidance learning, but suggest that such deficits cannot be attributed to altered GABA(A) or BDZ binding in brain. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave sleep deprivation
GABA
receptor autoradiography
inhibitory avoidance learning
Idioma Inglês
Data de publicação 2005-03-10
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1037, n. 1-2, p. 157-163, 2005.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 157-163
Fonte http://dx.doi.org/10.1016/j.brainres.2005.01.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228251400019
Endereço permanente http://repositorio.unifesp.br/handle/11600/28194

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