The impact of pronuclear orientation to select chromosomally normal embryos

The impact of pronuclear orientation to select chromosomally normal embryos

Autor Borges, E. Google Scholar
Rossi, L. M. Google Scholar
Farah, LMS Google Scholar
Guilherme, P. Google Scholar
Rocha, C. C. Google Scholar
Ortiz, V Google Scholar
Iaconelli, A. Google Scholar
Instituição Fertil Ctr Fertilizacao Assistida
Med Sch Jundiai
Genet Lab
Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: To find an effective method to select embryos from ICSI with better chromosomal status when preimplantation-genetic-diagnosis (PGD) is not applied.Methods: Several morpholological evaluations were done in same embryos. Embryos from ICSI were classified on day I according to pronuclear-nucleoli arrangement. On day 3, classification was done according to number, fragmentation, size and shape of cells. in some patients, embryos exhibiting good quality on day 3 (at least six regular blastomeres with cell fragmentation lower than 20%) were also submitted to PGD, irrespective to pronuclear-nucleoli morphology.Results: Forty-two per cent of normally fertilized embryos showed pronuclear-nucleoli-good-morphology; from those, 86% were also classified as good quality on day 3. Good-quality embryos submitted to PGD have shown lower chromosomal abnormality rates when also classified as pronuclear-nucleoli-good-morphology.Conclusions: Pronuclear-nucleoli morphology seems to be correlated with PGD results. This criterion may prove useful for pre-select embryos with normal chromosomal package when PGD is not applied.
Palavra-chave embryo selection
ICSI
PN morphology
preimplantation diagnosis
Idioma Inglês
Data de publicação 2005-03-01
Publicado em Journal of Assisted Reproduction and Genetics. New York: Springer/plenum Publishers, v. 22, n. 3, p. 107-114, 2005.
ISSN 1058-0468 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 107-114
Fonte http://dx.doi.org/10.1007/s10815-005-4874-x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230395700001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28173

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