Neuroendocrine effects of quetiapine in healthy volunteers

Neuroendocrine effects of quetiapine in healthy volunteers

Autor Guerra, Alexandro de Borja Gonçalves Autor UNIFESP Google Scholar
Castel, Saulo Autor UNIFESP Google Scholar
Benedito-Silva, Ana Amélia Autor UNIFESP Google Scholar
Calil, Helena Maria Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study measured prolactin, cortisol, ACTH and growth hormone in healthy male volunteers following an acute oral administration of quetiapine, an atypical antipsychotic with high affinity for H, and moderate affinity for sigma, sigma(1), 5-HT2, alpha(2) and D-2 receptors. Fifteen male volunteers entered this randomized double-blind, cross-over, placebo-controlled study. Blood samples were drawn every 30 min from 09:00 hours to 13:00 hours. the first samples were drawn immediately before the administration of 150 mg quetiapine or placebo. Mean results for each hormone and ANOVA for repeated measures were performed. the area under the curve (AUC) hormonal values were calculated and compared by paired t test. the ANOVA showed an increase of prolactin after quetiapine administration from time 60 min up to the end of the observation period. Cortisol decreased after quetiapine administration from time 150 min to time 240 min. ACTH secretion showed no difference compared to placebo. There was a late increase in growth hormone secretion, significant in comparison with placebo only at time 210 min. the AUC values were statistically different for prolactin and cortisol compared to placebo. A single dose of quetiapine (150 mg) increased prolactin secretion probably due to a transiently high D, receptor occupancy at the anterior pituitary. Cortisol secretion decreased as was expected from quetiapine's pharmacodynamic profile. the lack of response of ACTH might be, at least in part, explained by the low hormonal assay sensitivity. the late growth hormone increase might have been due to quetiapine's antagonism of H, receptors.
Palavra-chave ACTH
cortisol
growth hormone
prolactin
quetiapine
Idioma Inglês
Data de publicação 2005-03-01
Publicado em International Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 8, n. 1, p. 49-57, 2005.
ISSN 1461-1457 (Sherpa/Romeo, fator de impacto)
Publicador Cambridge Univ Press
Extensão 49-57
Fonte http://dx.doi.org/10.1017/S1461145704004705
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228033700006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28160

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