Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia

Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia

Autor Vicari, Perla Autor UNIFESP Google Scholar
Mello, Adriana Barretto de Autor UNIFESP Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Fetal hemoglobin (HbF) inhibits the polymerization of sickle hemoglobin, modulating the clinical features of sickle cell anemia (SCA). Hydroxyurea (HU) therapy can increase the HbF level, although its production can be influenced by genetic determinants. Twenty-two Brazilian SCA patients were evaluated over 5 years before and after HU use. We analyzed (1) beta(S) haplotype; (2) patient characteristics; and (3) toxicity. No differences between age, sex, and HU response were observed. We found 40.9% of homozygous for Bantu haplotype, and, in contrasting to other trials, we observed HbF level increase in this group (3.84-9.08 g/dL, P = 0.003). Adverse effects were rare. Labyrinthitis was observed in 2 (9.10%) patients after HU use, although this complication had not been described before.
Palavra-chave fetal hemoglobin
hydroxyurea
beta(s) haplotype
sickle cell anemia
Idioma Inglês
Data de publicação 2005-03-01
Publicado em American Journal of Hematology. Hoboken: Wiley-liss, v. 78, n. 3, p. 243-244, 2005.
ISSN 0361-8609 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 243-244
Fonte http://dx.doi.org/10.1002/ajh.20293
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000227412900015
Endereço permanente http://repositorio.unifesp.br/handle/11600/28158

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