The effects of dopaminergic agonists on genital reflexes in paradoxical sleep deprived male rats

Show simple item record

dc.contributor.author Andersen, M. L.
dc.contributor.author Tufik, S.
dc.date.accessioned 2016-01-24T12:37:40Z
dc.date.available 2016-01-24T12:37:40Z
dc.date.issued 2005-02-15
dc.identifier http://dx.doi.org/10.1016/j.physbeh.2004.11.007
dc.identifier.citation Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 84, n. 2, p. 205-210, 2005.
dc.identifier.issn 0031-9384
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28156
dc.description.abstract Dopamine (DA) agonists provide evidence that different receptor subtypes in the central nervous system (CNS) have influence in sexual behavior. Sleep deprivation induces supersensibility of DA receptors and previous work has shown that the DA agonist apomorphine enhances spontaneous genital reflexes (penile erection-PE and ejaculation-EJ) in rats deprived of paradoxical sleep. the present study sought to extend the latter finding by assessing the effects of other DA agonists in paradoxical sleep-deprived (PSD) male rats. the DA drugs (bromocriptine and piribedil) were acutely administered to rats that had been deprived of sleep for 4 days and to normal controls. Sleep deprivation alone induced PE and this effect was potentiated by piribedil, with maximal effects occurring with the 8 mg/kg dose, whereas only one dose of bromocriptine (8 mg/kg) induced more PE in PSD rats than in non-deprived treated controls. EJs were increased in piribedil PSD groups but this response was absent after bromocriptine treatment in the dose range tested. Our data show the genital reflexes that occurred in PSD rats are potentialized by piribedil and not by bromocriptine. These DA agonists showed distinct effects m sexual response suggesting that these effects are probably due to PSD-induced DA receptor supersensitivity even though different mechanisms are involved. (c) 2004 Elsevier Inc. All rights reserved. en
dc.format.extent 205-210
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Physiology & Behavior
dc.rights Acesso restrito
dc.subject sleep deprivation en
dc.subject sexual behavior en
dc.subject Piribedil en
dc.subject Bromocriptine en
dc.subject dopamine en
dc.subject erection en
dc.subject rat en
dc.title The effects of dopaminergic agonists on genital reflexes in paradoxical sleep deprived male rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.physbeh.2004.11.007
dc.description.source Web of Science
dc.identifier.wos WOS:000227362200004



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account