Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction

Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction

Autor Camara, NOS Google Scholar
Soares, M. P. Google Scholar
Instituição Gulbenkian Inst Sci
Universidade Federal de São Paulo (UNIFESP)
Resumo Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO) [1]. Expression of HO-1 regulates inflammatory and immune responses, such as those involved in the rejection of transplanted organs. We will discuss here accumulating evidence supporting the notion that expression of HO-1 in a transplanted organ can prevent its rejection. We will argue that the protective effects exerted by HO-1 are mediated to a large extent by the end products that it generates via the catabolism of heme. Better knowledge of how to enhance these protective effects is likely to help create new therapeutic strategies to improve the outcome of transplanted organs. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave free radicals
heme oxygenase-1
carbon monoxide
transplantation
protective gene
inflarmation
endothelial
Idioma Inglês
Data de publicação 2005-02-15
Publicado em Free Radical Biology and Medicine. Oxford: Pergamon-Elsevier B.V., v. 38, n. 4, p. 426-435, 2005.
ISSN 0891-5849 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 426-435
Fonte http://dx.doi.org/10.1016/j.freeradbiomed.2004.11.019
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000226922400003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28155

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