Telomere and subtelomere of Trypanosoma cruzi chromosomes are enriched in (pseudo)genes of retrotransposon hot spot and trans-sialidase-like gene families: the origins of T-cruzi telomeres

Telomere and subtelomere of Trypanosoma cruzi chromosomes are enriched in (pseudo)genes of retrotransposon hot spot and trans-sialidase-like gene families: the origins of T-cruzi telomeres

Autor Kim, D. Google Scholar
Chiurillo, M. A. Google Scholar
El-Sayed, N. Google Scholar
Jones, K. Google Scholar
Santos, MRM Google Scholar
Porcile, P. E. Google Scholar
Andersson, B. Google Scholar
Myler, P. Google Scholar
Silveira, J. F. da Google Scholar
Ramirez, J. L. Google Scholar
Instituição IDEA
Universidade Federal de São Paulo (UNIFESP)
Univ Ctr Occidental Lisandro Alvarado
Inst Genom Res
Karolinska Inst
Seattle Biomed Res Inst
Cent Univ Venezuela
Resumo Here, we sequenced two large telomeric regions obtained from the pathogen protozoan Trypanosoma cruzi. These sequences, together with in silico assembled contigs, allowed us to establish the general features of telomeres and subtelomeres of this parasite. Our findings can be summarized as follows: We confirmed the presence of two types of telomeric ends; subtelomeric regions appeared to be enriched in (pseudo)genes of RHS (retrotransposon hot spot), TS (trans-sialidase)-like proteins, and putative surface protein DGF-1 (dispersed gene family-1). Sequence analysis of the ts-like genes located at the telomeres suggested that T. cruzi chromosomal ends could have been the site for generation of new gp85 variants, an important adhesin molecule involved in the invasion of mammalian cells by T. cruzi. Finally, a mechanism for generation of T. cruzi telomere by chromosome breakage and telomere healing is proposed. (c) 2004 Elsevier B.V. All rights reserved.
Palavra-chave pathogen protozoan
chromosome end organization
surface protein genes
retrotransposon Hot Spot multigene family
telomere healing
Idioma Inglês
Data de publicação 2005-02-14
Publicado em Gene. Amsterdam: Elsevier B.V., v. 346, p. 153-161, 2005.
ISSN 0378-1119 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 153-161
Fonte http://dx.doi.org/10.1016/j.gene.2004.10.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227900000017
Endereço permanente http://repositorio.unifesp.br/handle/11600/28154

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