Strict red blood cell transfusion guideline reduces the need for transfusions in very-low-birthweight infants in the first 4 weeks of life: a multicentre trial

Strict red blood cell transfusion guideline reduces the need for transfusions in very-low-birthweight infants in the first 4 weeks of life: a multicentre trial

Autor Dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
Santos, N. dos Google Scholar
Guinsburg, Ruth Autor UNIFESP Google Scholar
Kopelman, B. I. Google Scholar
Araujo Peres, C. de Google Scholar
Lima Taga, M. F. de Google Scholar
Shinzato, A. R. Google Scholar
Costa, HDF Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background and Objectives Very-low-birthweight infants are among the most heavily transfused patients. the objective of this study was to verify if the introduction of a strict guideline would reduce the need for red blood cell transfusions in the first 4 weeks of life in these neonates.Materials and Methods This was a multicentre prospective study of two cohorts of very-low-birthweight infants transfused in accordance with the recommendations of a neonatologist (Phase 1) or according to previously published guidelines (Phase 2).Results in the first 28 days of life, 102 patients (68.5%) in Phase 1 and 117 (59.7%) in Phase 2 were transfused. the number of transfusions was 1.9 +/- 2.0 in Phase 1 and 1.4 +/- 1.6 in Phase 2 (P = 0.01). After adjusting for gestational age, blood loss and the presence of respiratory distress syndrome, the strict guideline reduced the number of transfusions in 17.6% (IC 95%-30.5% to -2.6%).Conclusions the strict guideline was effective in reducing erythrocyte transfusions in very-low-birthweight infants.
Palavra-chave anaemia
blood transfusion
newborn infant
premature infant
Idioma Inglês
Data de publicação 2005-02-01
Publicado em Vox Sanguinis. Oxford: Blackwell Publishing Ltd, v. 88, n. 2, p. 107-113, 2005.
ISSN 0042-9007 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Ltd
Extensão 107-113
Fonte http://dx.doi.org/10.1111/j.1423-0410.2005.00607.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227129900006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28151

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