Iron overload in patients with chronic hepatitis C virus infection: Clinical and histological study

Iron overload in patients with chronic hepatitis C virus infection: Clinical and histological study

Autor Silva, VSS Google Scholar
Perez, R. M. Google Scholar
Oliveira, P. V. Google Scholar
Cantagalo, M. I. Google Scholar
Dantas, E. Google Scholar
Sisti, C. Google Scholar
Figueiredo-Mendes, C. Google Scholar
Lanzoni, V. P. Google Scholar
Silva, AEB Google Scholar
Ferraz, MLG Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Background: Recently it has been found that iron is an important element in the natural history of hepatitis C. Serum markers of iron stores are frequently increased in chronic hepatitis C virus (HCV)infected carriers but the real impact of the hepatic iron overload is poorly understood. the purpose of the present paper was to determine the prevalence of iron overload and to study the relationship between hepatic iron concentration (HIC) and clinical, biochemical and histological characteristics in chronic HCV-infected carriers.Methods: Patients presenting with anti-HCV and HCV-RNA were included. Hepatic iron concentration was determined in liver tissue by atomic absorption spectrophotometry. the association between HIC and age, gender, risk factor of transmission, duration of infection, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, iron and serum ferritin, transferrin saturation, HCV-RNA level, grading of inflammatory activity, staging of fibrosis, hepatic steatosis, and stainable iron was analyzed. Statistical analysis included the Mann-Whitney test and a multiple linear regression model.Results: Ninety-six patients (58% male) with a mean age of 44 10 years were studied. Serum iron, ferritin and transferrin saturation were elevated in 28%, 27% and 12.5% of patients, respectively. Stainable iron was detected in few patients (15.6%). Higher grades of stainable iron (2 and 3) were observed in only 7%. the HIC (>30 mmol/g dry weight) was elevated in five patients (5%). Neither grading nor staging were related to HIC. Higher HIC were observed in male patients (P <0.001), in patients with elevated serum ferritin (P = 0.001) and in patients with stainable iron (grades 2 and 3. P = 0.001). Multiple linear regression analysis showed that only stainable iron was independently correlated with HIC (P = 0.003).Conclusions: Iron overload in chronically HCV-infected patients was uncommon and hepatic iron content seemed not to be related to the liver damage process. in the eventuality of iron overload, histochemical liver iron is a useful marker to estimate HIC. (C) 2004 Blackwell Publishing Asia Pty Ltd.
Idioma Inglês
Data 2005-02-01
Publicado em Journal of Gastroenterology and Hepatology. Hoboken: Wiley-Blackwell, v. 20, n. 2, p. 243-248, 2005.
ISSN 0815-9319 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 243-248
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227609900012

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