Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and F recombinants in São Paulo, Brazil

Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and F recombinants in São Paulo, Brazil

Autor De Sa, D. J. Google Scholar
Sanabani, S. Google Scholar
Diaz, R. S. Google Scholar
Munerato, P. Google Scholar
Brunstein, A. Google Scholar
Fusuma, E. Google Scholar
Sabino, E. C. Google Scholar
Janini, L. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fdn Prosangue Hemoctr
Resumo Recombination is one of the major mechanisms contributing to human immunodeficiency virus type I (HIV-1) variability. Analysis of pol gene sequences of 215 HIV-1 samples from São Paulo, Brazil classified 189 sequences as subtype B (87.9%), 8 sequences as subtype F (3.7%), and 18 sequences (8.4%) as B/F recombinants. After the analysis of the pol gene, a subset of six recombinant samples composed of sequences with a related recombinant pol structure was selected for full-length genome analysis to identify a possible circulating recombinant form. According to full-length genome analysis, recombination was higher in gag, protease, reverse transcriptase, integrase, and vif. Identification of many distinct recombinant forms and the absence of an identifiable HIV-1 circulating recombinant form suggest that a high frequency of dual infections between HIV-1 subtypes B and F is occurring in São Paulo, Brazil.
Idioma Inglês
Data de publicação 2005-02-01
Publicado em Aids Research and Human Retroviruses. Larchmont: Mary Ann Liebert Inc, v. 21, n. 2, p. 145-151, 2005.
ISSN 0889-2229 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc
Extensão 145-151
Fonte http://dx.doi.org/10.1089/aid.2005.21.145
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227355500005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28148

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