Effect of Electroacupuncture on bronchial asthma induced by ovalbumin in rats

Effect of Electroacupuncture on bronchial asthma induced by ovalbumin in rats

Autor Carneiro, E. R. Google Scholar
Carneiro, CRW Google Scholar
De Castro, MAP Google Scholar
Yamamura, Y. Google Scholar
Silveira, VLF Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Introduction: Asthma is a worldwide disabling chronic inflammatory airway disease characterized by an intense eosinophilic inflammatory infiltrate on bronchial mucous membranes. Among the complementary therapeutic approaches to asthma, acupuncture has been widely used.Objective: Here we used a rat pulmonary hypersensitivity experimental model that mimics human asthma in order to address whether electroacupuncture (EA) treatment could reduce the inflammatory process.Materials and Methods: Experimental animals were divided in four groups: control (C), immobilized (1), sham-acupuncture (SA), and acupuncture (A). All rats were sensitized with heat-solidified hen egg white implant. Using clinical acupuncture points, EA treatment began 2 days after antigen priming and was repeated on alternate days for 2 weeks. Subsequently, animals were challenged by inhalation with aggregated ovalbumin and sacrificed 24 hours later when blood samples, bronchoalveolar lavage (BAL), and lungs were collected.Results: Histopathologic analyses showed that peribronchial and perivascular inflammatory cell infiltrates were significantly lower in group A compared to groups SA and I (shown to be similar to group C). Furthermore, BAL total cell count and percentage of polymorphonuclears (as well as the differential counts of neutrophils and eosinophils) were significantly reduced in group A compared to group 1. Corsticosterone plasma levels were similar in all groups.Conclusions: Taken together these results show that EA efficiently diminishes the bronchial immune-mediated inflammation induced in rats and that this effect is dependent on the choice of specific acupoints.
Idioma Inglês
Data 2005-02-01
Publicado em Journal of Alternative and Complementary Medicine. Larchmont: Mary Ann Liebert Inc, v. 11, n. 1, p. 127-134, 2005.
ISSN 1075-5535 (Sherpa/Romeo, fator de impacto)
Editor Mary Ann Liebert Inc
Extensão 127-134
Fonte http://dx.doi.org/10.1089/acm.2005.11.127
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227477300018
URI http://repositorio.unifesp.br/handle/11600/28147

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