Acute cocaine effects in paradoxical sleep deprived male rats

Acute cocaine effects in paradoxical sleep deprived male rats

Autor Andersen, M. L. Google Scholar
Perry, J. C. Google Scholar
Tuflk, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Cocaine is a psychomotor drug known to cause behavioural alterations. This study was conducted to characterize behavioural response to acute cocaine injection (7 mg/kg, ip) in paradoxical sleep deprived (PSD) male rats since sleep deprivation is also associated with several behavioural alterations. Cocaine or vehicle was administered to rats at the end of a 4-day period of sleep deprivation, and in home-cage control animals. Cocaine administration in control and PSD rats induced a significant increase in stereotyped behaviour in relation to saline-injected rats. PSD induced significant but heterogeneous effects in animals by increasing grooming while it had effect neither on stereotyped behaviours, locomotion nor on anxiety-like behaviours but significantly decreased rearing behaviour. PSD potentiates the action of cocaine on stereotyped behaviours suggesting supersensitivity of dopaminergic receptors. Thus, the present study indicated that the behavioural effects of cocaine could be modified by PSD. This in turn may have relevant implications in the cocaine effect in abusers under sleep deprived condition. (C) 2004 Elsevier Inc. All rights reserved.
Assunto anxiety
open field
sleep deprivation
Idioma Inglês
Data 2005-02-01
Publicado em Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 29, n. 2, p. 245-251, 2005.
ISSN 0278-5846 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 245-251
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000227115100007

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