Hemodynamic and metabolic effects of angiotensin II on the liver

Hemodynamic and metabolic effects of angiotensin II on the liver

Autor Nascimento, T. A. Google Scholar
Gioli-Pereira, L. Google Scholar
Carvalho, L. T. Google Scholar
Santos, E. L. Google Scholar
Pesquero, J. B. Google Scholar
Kouyoumdjian, M. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Maringá (UEM)
Resumo To ascertain the mechanism of interaction between angiotensins (AI and AII) and the liver. an angiotensin-converting enzyme inhibitor (captopril) and a receptor antagonist (losartan) were used. Monovascular or bivascular liver perfusion was used to assess both hemodynamic (portal and arterial hypertensive responses) and metabolic (glucose production and oxygen consumption) effects. Microphysiometry was used for isolated liver cell assays to assess AII or losartan membrane receptor-mediated interaction. Captopril abolishes portal hypertensive response (PHR) to AI but not the AII effect. AII infused via the portal pathway promotes calcium-dependent PHR but not a hypertensive response in the arterial pathway (AHR); when infused into the arterial pathway AII promotes calcium-dependent PHR and AHR. Losartan infused into the portal vein abolishes PHR to AII but not the metabolic response: when infused via both pathways it abolishes the hypertensive responses and inhibits the metabolic effects. Isolated liver cells specifically respond to AII Sinusoidal cells, but not hepatocytes. respond to 10 nM losartan. We conclude that AI has to be converted to AII to produce PHR. Quiescent stellate cells interacts in vitro with AII and losartan. Hemodynamic responses to AII are losartan-dependent but metabolic responses are partially losarian-independent, AII hemodynamic actions are mainly presinusoidal. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave angiotensin
angiotensin-converting enzyme
bivascular liver perfusion
portal hypertension
angiotensin receptor
losartan
Idioma Inglês
Data de publicação 2005-02-01
Publicado em Peptides. New York: Elsevier B.V., v. 26, n. 2, p. 315-322, 2005.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 315-322
Fonte http://dx.doi.org/10.1016/j.peptides.2004.09.017
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000226429700018
Endereço permanente http://repositorio.unifesp.br/handle/11600/28141

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