Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin

Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin

Autor Corbi, P. P. Google Scholar
Massabni, A. C. Google Scholar
Moreira, A. G. Google Scholar
Medrano, F. J. Google Scholar
Jasiulionis, M. G. Autor UNIFESP Google Scholar
Costa-Neto, C. M. Google Scholar
Instituição UNESP
Universidade de São Paulo (USP)
LNLS
Universidade Federal de São Paulo (UNIFESP)
Resumo Synthesis, characterization, and biological activity of a new water-soluble Pd(II)-deoxyalliin (S-allyl-L-cysteine) complex are described in this article. Elemental and thermal analysis for the complex are consistent with the formula [Pd(C6H10NO2S)(2)]. C-13 NMR, H-1 NMR, and IR spectroscopy show coordination of the ligand to Pd(II) through S and N atoms in a square planar geometry. Final residue of the thermal treatment was identified as a mixture of PdO and metallic Pd. Antiproliferative assays using aqueous solutions of the complex against HeLa and TM5 tumor cells showed a pronounced activity of the complex even at low concentrations. After incubation for 24 h, the complex induced cytotoxic effect over HeLa cells when used at concentrations higher than 0.40 mmol/L. At lower concentrations, the complex was nontoxic, indicating its action is probably due to cell cycle arrest, rather than cell death. in agreement with these results, the flow cytometric analysis indicated that after incubation for 24 h at low concentrations of the complex cells are arrested in G0/G1.
Assunto palladium( II)
deoxyalliin
S-allyl-L-cysteine
tumor cells
cancer
Idioma Inglês
Data 2005-02-01
Publicado em Canadian Journal of Chemistry-revue Canadienne de Chimie. Ottawa: Natl Research Council Canada, v. 83, n. 2, p. 104-109, 2005.
ISSN 0008-4042 (Sherpa/Romeo, fator de impacto)
Editor Natl Research Council Canada
Extensão 104-109
Fonte http://dx.doi.org/10.1139/V05-003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228084200003
URI http://repositorio.unifesp.br/handle/11600/28128

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