Antimicrobial activity of dalbavancin tested against Gram-positive clinical isolates from Latin American medical centres

Antimicrobial activity of dalbavancin tested against Gram-positive clinical isolates from Latin American medical centres

Autor Gales, Ana Crisitna Autor UNIFESP Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Jones, R. N. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
JONES Grp
Tufts Univ
Resumo The activity of dalbavancin, a new semi-synthetic lipoglycopeptide antibiotic, was evaluated in comparison with other antibacterial agents against 1229 Gram-positive organisms collected from medical centres in Latin America. Dalbavancin was the most potent compound tested against isolates of Staphylococcus aureus (MIC50, 0.06 mg/L) and coagulase-negative staphylococci (MIC50, 0.03 mg/L), independently of methicillin susceptibility. Dalbavancin inhibited all Streptococcus pneumoniae isolates at less than or equal to 0.06 mg/L. Dalbavancin also demonstrated excellent activity against beta-haemolytic (MIC50, less than or equal to 0.008 mg/L) and viridans group (MIC50, 0.016 mg/L) streptococci. All vancomycin-susceptible Enterococcus spp. isolates were inhibited by dalbavancin at less than or equal to 0.25 mg/L, but some vancomycin-resistant Enterococcus spp. isolates were only inhibited by dalbavancin levels of greater than or equal to 8 mg/L. Dalbavancin exhibited excellent activity against isolates of Corynebacterium spp. and Listeria spp. Dalbavancin may provide an important therapeutic option for Gram-positive infections, excluding those caused by enterococci with VanA-type resistance.
Palavra-chave Dalbavancin
enterococci
Gram-positive cocci
Latin America
staphylococci
streptococci
Idioma Inglês
Data de publicação 2005-02-01
Publicado em Clinical Microbiology and Infection. Oxford: Blackwell Publishing Ltd, v. 11, n. 2, p. 95-100, 2005.
ISSN 1198-743X (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Ltd
Extensão 95-100
Fonte http://dx.doi.org/10.1111/j.1469-0691.2004.01051.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000226641300003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28125

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