Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Autor Ram, Felix SF Google Scholar
Jardim, José Roberto Google Scholar
Atallah, Álvaro Nagib Autor UNIFESP Google Scholar
Castro, Aldemar Araujo Autor UNIFESP Google Scholar
Mazzini, Renato Coimbra Autor UNIFESP Google Scholar
Goldstein, Roger Google Scholar
Lacasse, Yves Google Scholar
Cendon Filha, Sônia Perez Autor UNIFESP Google Scholar
Instituição Natl Collaborating Ctr Womens & Childrens Hlth
Universidade Federal de São Paulo (UNIFESP)
Emergency Med Div
Fed Univ Alagoas
Univ Toronto
Univ Laval
Resumo Objectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave COPD
oral
theophylline
systematic review
meta-analysis
cochrane
Idioma Inglês
Data de publicação 2005-02-01
Publicado em Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005.
ISSN 0954-6111 (Sherpa/Romeo, fator de impacto)
Publicador W B Saunders Co Ltd
Extensão 135-144
Fonte http://dx.doi.org/10.1016/j.rmed.2004.10.009
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000226879600001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28120

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