Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli

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dc.contributor.author Bellini, E. M.
dc.contributor.author Elias Junior, Waldir Pereira [UNIFESP]
dc.contributor.author Gomes, Tania Aparecida Tardelli [UNIFESP]
dc.contributor.author Tanaka, T. L.
dc.contributor.author Taddei, C. R.
dc.contributor.author Huerta, R.
dc.contributor.author Navarro-Garcia, F.
dc.contributor.author Martinez, M. B.
dc.date.accessioned 2016-01-24T12:37:36Z
dc.date.available 2016-01-24T12:37:36Z
dc.date.issued 2005-02-01
dc.identifier http://dx.doi.org/10.1016/j.femsim.2004.08.008
dc.identifier.citation Fems Immunology and Medical Microbiology. Amsterdam: Elsevier B.V., v. 43, n. 2, p. 259-264, 2005.
dc.identifier.issn 0928-8244
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28119
dc.description.abstract Enteroaggregative Escherichia eoli (EAEC) is an emerging cause of pediatric and adult travellers diarrhea. the mechanism by which EAEC induce diarrhea is not completely known. Two serine protease autotransporter proteins, named Pet and Pic have been identified in EAEC strains. Pet has enterotoxic and cytotoxic activities, while the role of Pic in pathogenesis may lie on its mucinolytic activity. Little is known about Pet and Pic biological activities in vivo. in this study the antibody responses against these autotransporter proteins in convalescent children is investigated. Fifteen (83%) children showed specific antibodies against Pet or Pic in their sera. IgG and IgM antibodies were the main isotype found. Specific antibodies against Pic, but not against Pet, were detected in sera from age-matched control group. These data show that specific anti-Pet and anti-Pic antibodies are produced during the course of a natural EAEC infection in children. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. en
dc.format.extent 259-264
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Fems Immunology and Medical Microbiology
dc.rights Acesso aberto
dc.subject EAEC en
dc.subject Pet en
dc.subject Pic en
dc.subject antibody response en
dc.subject IgG en
dc.subject IgM en
dc.subject IgA en
dc.subject diarrhea en
dc.subject children en
dc.title Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Inst Butantan
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution CINVESTAV
dc.description.affiliation Univ São Paulo, Dept Microbiol, Inst Ciencias Biomed, São Paulo, Brazil
dc.description.affiliation Inst Butantan, Lab Especial Microbiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 São Paulo, Brazil
dc.description.affiliation CINVESTAV, IPN, Dept Cell Biol, Mexico City 14000, DF, Mexico
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.femsim.2004.08.008
dc.description.source Web of Science
dc.identifier.wos WOS:000226989800019



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