Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli

Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli

Autor Bellini, E. M. Google Scholar
Elias Junior, Waldir Pereira Autor UNIFESP Google Scholar
Gomes, Tania Aparecida Tardelli Autor UNIFESP Google Scholar
Tanaka, T. L. Google Scholar
Taddei, C. R. Google Scholar
Huerta, R. Google Scholar
Navarro-Garcia, F. Google Scholar
Martinez, M. B. Google Scholar
Instituição Universidade de São Paulo (USP)
Inst Butantan
Universidade Federal de São Paulo (UNIFESP)
CINVESTAV
Resumo Enteroaggregative Escherichia eoli (EAEC) is an emerging cause of pediatric and adult travellers diarrhea. the mechanism by which EAEC induce diarrhea is not completely known. Two serine protease autotransporter proteins, named Pet and Pic have been identified in EAEC strains. Pet has enterotoxic and cytotoxic activities, while the role of Pic in pathogenesis may lie on its mucinolytic activity. Little is known about Pet and Pic biological activities in vivo. in this study the antibody responses against these autotransporter proteins in convalescent children is investigated. Fifteen (83%) children showed specific antibodies against Pet or Pic in their sera. IgG and IgM antibodies were the main isotype found. Specific antibodies against Pic, but not against Pet, were detected in sera from age-matched control group. These data show that specific anti-Pet and anti-Pic antibodies are produced during the course of a natural EAEC infection in children. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Assunto EAEC
Pet
Pic
antibody response
IgG
IgM
IgA
diarrhea
children
Idioma Inglês
Data 2005-02-01
Publicado em Fems Immunology and Medical Microbiology. Amsterdam: Elsevier B.V., v. 43, n. 2, p. 259-264, 2005.
ISSN 0928-8244 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 259-264
Fonte http://dx.doi.org/10.1016/j.femsim.2004.08.008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000226989800019
URI http://repositorio.unifesp.br/handle/11600/28119

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