Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study

Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study

Autor Sanches, M. Google Scholar
Sassi, R. B. Google Scholar
Axelson, D. Google Scholar
Nicoletti, M. Google Scholar
Brambilla, P. Google Scholar
Hatch, J. P. Google Scholar
Keshavan, M. S. Google Scholar
Ryan, N. D. Google Scholar
Birmaher, B. Google Scholar
Soares, J. C. Google Scholar
Instituição Univ Texas
S Texas Vet Hlth Care Syst
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Pittsburgh
Univ Udine
Resumo The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. the sample consisted of 15 children and adolescents who met DSM-IV criteria for bipolar disorder (mean age S.D.=15.5 +/- 3.5 years) and 21 healthy adolescents (mean age S.D.=16.9 +/- 3.8 years). MR images were obtained with a 1.5 T GE Signa Imaging System with Signa 5.4.3 software. SGPFC volumes were measured with the semi-automated software MedX (Sensor Systems, Sterling, VA, USA). ANCOVA was performed to compare SGPFC volumes between groups, using age, gender and intra-cranial volume (ICV) as covariates. the volumes (mean +/- S.D.) of the right and left SGPFC for bipolar patients were 291.27 +/- 88.70 mm(3) and 284.86 +/- 83.98 mm(3), respectively. for healthy controls, the right and left SGPFC volumes were 284.95 +/- 73.33 mm(3) and 307.55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave neuroimaging
prefrontal cortex
bipolar disorder
adolescents
Idioma Inglês
Data de publicação 2005-01-30
Publicado em Psychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 138, n. 1, p. 43-49, 2005.
ISSN 0925-4927 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 43-49
Fonte http://dx.doi.org/10.1016/j.pscychresns.2004.11.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227611300005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28117

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