Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene

Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene

Autor Passaglio, K. T. Google Scholar
Baltatu, O. Google Scholar
Machado, R. P. Google Scholar
Reis, A. M. dos Google Scholar
Pesquero, J. B. Google Scholar
Bader, M. Google Scholar
Santos, RAS Google Scholar
Instituição Universidade Federal de Minas Gerais (UFMG)
Max Delbruck Ctr Mol Med
Univ Fed Ouro Preto
Universidade Federal de São Paulo (UNIFESP)
Resumo The renal response to acute volume expansion was investigated in transgenic (TGR) rats harboring the human tissue kallikrein gene. After a printer injection of 0.9% NaCl (3 ml/100 g, i.v), Sprague-Dawley (SD) or TGR rats received a continuous infusion of 0.9% NaCl (15 mul/ 100 g/min, i.a.) through a catheter placed into the carotid artery. Acute volume expansion was produced by a second injection of 0.9% NaCl (2 ml/100 g, i.v.) 65 min after the first injection. Plasma vasopressin (AVP) and atrial natriuretic peptide (ANP) concentration was measured before and within 10 min of volume expansion. TGR animals presented a blunted response to acute volume expansion evidenced by an attenuated increase in total and fractional water and sodium excretion. Before or after volume expansion, plasma AVP and ANP did not differ between SD and TGR. Pre-treatment with the BK-B-2 antagonist HOE-140 (7.5 mug/100 g. i.a) partially improved the renal response of TGRs and severely blunted the response in SD rats. These data show that TGR (hKLK1) rats have an impaired renal response to acute volume expansion that can not be accounted for by changes in the release of AVP or ANP. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave kinins
transgenic rats
human genes
Idioma Inglês
Data de publicação 2005-01-15
Publicado em Regulatory Peptides. Amsterdam: Elsevier B.V., v. 124, n. 1-3, p. 127-135, 2005.
ISSN 0167-0115 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 127-135
Fonte http://dx.doi.org/10.1016/j.regpep.2004.07.008
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000225638300016
Endereço permanente http://repositorio.unifesp.br/handle/11600/28114

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