High prevalence of vertebral deformity in premenopausal systemic lupus erythematosus patients

High prevalence of vertebral deformity in premenopausal systemic lupus erythematosus patients

Autor Borba, VCZ Google Scholar
Matos, P. G. Google Scholar
Viana, PRD Google Scholar
Fernandes, A. Google Scholar
Sato, E. I. Google Scholar
Lazaretti-Castro, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Resumo In this paper we searched for vertebral deformities in a group of 70 premenopausal systemic lupus erythematosus (SLE) patients (31.8 +/- 8.1 years old) and compared them to a matched control group of 22 healthy women (32.0 +/- 8.9 years old). Patients and controls performed spine X-ray (XR) morphometry and lumbar spine and femoral neck bone mineral density (BMD). Clinical data was obtained by a questionnaire and charts review. Thoracic or lumbar spine fracture was observed in 15 (21.4%) SLE patients, while no deformities were found in the control group (P = 0.018). BMD was not different amongst SLE patients and controls and between SLE patients with or without deformities. Although BMD could not predict what patient have deformity, seven patients (46.6%) with deformity had a lumbar spine or femoral neck Z-score less than - 1 SD [median = - 0.59 (- 3.72 to + 0.88) and - 0.20 (- 4.05 to + 1.87)] respectively. in addition, we found a negative correlation between number of fracture per patient and lumbar spine and femoral neck BMD (R = 0.58, P = 0.04 and R = 0.84, P = < 0.0001 respectively). No significant correlation was found between number of deformities and clinical data. This is the first study to search for vertebral deformities in SLE patients and to demonstrate a high prevalence of deformities in a relative young SLE population. These findings bring up the necessity to look for spine deformities in this group of women regardless the BMD.
Palavra-chave BMD
corticosteroids
fracture
systemic lupus erythematosus
vertebral deformity
Idioma Inglês
Data de publicação 2005-01-01
Publicado em Lupus. London: Arnold, Hodder Headline Plc, v. 14, n. 7, p. 529-533, 2005.
ISSN 0961-2033 (Sherpa/Romeo, fator de impacto)
Publicador Arnold, Hodder Headline Plc
Extensão 529-533
Fonte http://dx.doi.org/10.1191/0961203305lu2154oa
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231359700007
Endereço permanente http://repositorio.unifesp.br/handle/11600/28108

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