Estrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysis

Estrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysis

Autor Heilberg, I. P. Google Scholar
Hernandez, E. Google Scholar
Alonzo, E. Google Scholar
Valera, R. Google Scholar
Ferreira, L. G. Google Scholar
Gomes, S. A. Google Scholar
Bellorin-Font, E. Google Scholar
Weisinger, JR Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Cent Univ Venezuela
Resumo The estrogen receptor (ER) gene has been considered as a candidate genetic marker for osteoporosis, and PvuII and XbaI polymorphisms of the ER alpha gene have been associated with low bone mineral density (BMD). We investigated whether ER polymorphism could predict the response of BMD in 28 postmenopausal women on hemodialysis with marked osteopenia or osteoporosis, randomized to receive raloxifene, a selective estrogen receptor modulator (SERM), or placebo for I year. BMD was assessed by dual X-ray absorptiometry and PvuII and XbaI restriction fragment-length polymorphism of the ER gene was determined using polymerase chain reaction. Baseline lumbar spine or femoral neck BMD parameters were not different between patients presenting either homozygous PP or xx when compared with heterozygous Pp or Xx genotypes. After 1 year, patients on raloxifene, presenting with PP or xx genotypes (but not those with Pp or Xx), showed a significantly higher mean lumbar spine BMD (0.942 +/- 0.18 vs. 0.925 +/- 0.17 2 g/cm(2), p <.01) and lower serum pyridinoline (19.7 +/- 9.7 vs. 30.6 +/- 16.5 nmol/L, p <.02) when compared with baseline values. No changes were detected in the placebo-treated patients or in the femur neck sites. in conclusion, after I year on raloxifene, postmenopausal osteoporotic women on chronic hemodialysis, homozygous for the P or x (PP or xx) alleles of the ER, exhibited a better lumbar spine BMD response and decreased serum pyridinoline values when compared with heterozygous women (Pp or Xx), suggesting that ER alpha allelic variants may explain, at least in part, the different outcomes after treatment of osteoporosis with SERM.
Palavra-chave estrogen receptor polymorphism
bone mineral density
postmenopausal osteoporosis
selective estrogen receptor modulator
raloxifene
Idioma Inglês
Data de publicação 2005-01-01
Publicado em Renal Failure. Philadelphia: Taylor & Francis Inc, v. 27, n. 2, p. 155-161, 2005.
ISSN 0886-022X (Sherpa/Romeo, fator de impacto)
Publicador Taylor & Francis Inc
Extensão 155-161
Fonte http://dx.doi.org/10.1081/JDI-48241
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000227929600005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28098

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