FTY720 prevents renal T-Cell infiltration after ischemia/reperfusion injury

FTY720 prevents renal T-Cell infiltration after ischemia/reperfusion injury

Autor Suleiman, M. Google Scholar
Cury, P. M. Google Scholar
Pestana, JOM Google Scholar
Burdmann, E. A. Google Scholar
Bueno, V Google Scholar
Instituição FAMERP
Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Resumo Ischemia/reperfusion (I/R) injury, a common early feature in renal transplantation, results from both free radical species generation and local inflammatory responses that attract different types of cells. the interaction with infiltrating leukocytes could promote damage and death of resident renal cells contributing to worsening of renal function. It has been shown that depletion of host T cells protects against kidney damage after I/R injury, although the mechanism is not fully understood. FTY720, a synthetic analog of a natural product extracted from Isaria sincclairii has shown modulatory properties in experimental models of autoimmune disease, transplantation, and I/R injury. FTY720 alters lymphocyte responses to chemokine homing signals, thereby decreasing the number of lymphocytes in inflammatory sites. We evaluated renal function in mice at 3, 5, and 7 days after I/R injury in the presence or absence of FTY720 treatment. FTY720 treatment promoted earlier recovery of renal function associated with a lower number of renal-infiltrating lymphocytes. These findings confirm previous results showing a protective effect of FTY720 in I/R injury models.
Idioma Inglês
Data 2005-01-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 37, n. 1, p. 373-374, 2005.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 373-374
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.12.280
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000228091300124
URI http://repositorio.unifesp.br/handle/11600/28092

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