Decreased Cytomegalovirus infection after antilymphocyte therapy in sirolimus-treated renal transplant patients

Decreased Cytomegalovirus infection after antilymphocyte therapy in sirolimus-treated renal transplant patients

Autor Ozaki, K. S. Google Scholar
Camara, NOS Google Scholar
Galante, N. Z. Google Scholar
Camargo, LFA Google Scholar
Pacheco-Silva, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Cytomegalovirus (CMV) infection is highly prevalent in transplant patients, especially in those submitted to a more intense immunosuppression. We monitored CMV infection in 34 patients during 60 days after antilymphocyte therapy without CMV prophylaxis. Six patients received sirolimus and 28 received no sirolimus as immunosuppression. During 60 days, of follow-up time, 24/28 (86%) patients who did not use sirolimus developed CMV infection at a mean time of 32.43 +/- 13.61 days after antilymphocyte treatment. in contrast, no patient on sirolimus had CMV infection during the same follow-up (p<0.001). During a further 4-month follow-up, six patients on sirolimus-free therapy had recurrence of CMV 46.5 +/- 18.5 days after them first episode. During this same period, one patient receiving sirolimus had one positive cell for CMV antigenemia, 169 days, after antilymphocyte therapy. in conclusion, the use of sirolimus significantly reduced the incidence of CMV infection in patients treated with antilymphocyte antibodies. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave cytomegalovirus
sirolimus
renal transplantation
Idioma Inglês
Data de publicação 2005-01-01
Publicado em International Immunopharmacology. Amsterdam: Elsevier B.V., v. 5, n. 1, p. 103-106, 2005.
ISSN 1567-5769 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 103-106
Fonte http://dx.doi.org/10.1016/j.intimp.2004.09.008
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000226615400015
Endereço permanente http://repositorio.unifesp.br/handle/11600/28080

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