Mechanical bowel preparation for elective colorectal surgery

Mechanical bowel preparation for elective colorectal surgery

Autor Guenaga, K. F. Google Scholar
Matos, D. Google Scholar
Castro, A. A. Google Scholar
Atallah, A. N. Google Scholar
Wille-Jorgensen, P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background for over a century the presence of bowel content during surgery has been linked to anastomotic leakage. Mechanical bowel preparation has been considered an efficient agent against leakage and infectous complications. This dogma is not based on solid evidence, but on observational data and expert's opinions.Objectives To determine the effectiveness and safety of prophylactic mechanical bowel preparation for morbidity and mortality rates in elective colorectal surgery.Search strategy We searched MEDLINE, EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials. We also searched relevant medical journals, and conference proceedings from major gastroenterological congresses and contacted experts in the field. We used the search strategy described by the Colorectal Cancer Review Group, without limitations for date of publication and language. ISelection criteria Randomised, clinical trials that compared any strategy in mechanical bowel preparation with no mechanical bowel preparation.Data collection and analysis Data were independently extracted by the reviewers and cross-checked. the same reviewers assessed the methodological quality of each trial. Details of the randomisation (generation and concealment), blinding, whether an intention-to-treat analysis was done, and the number of patients lost to follow-up was recorded. for analysis the Peto odds ratio (OR) was used as defaults.Main results of the 1592 patients (9 trials), 789 were allocated to mechanical bowel preparation (Group A) and 803 to no preparation (Group B) before elective colorectal surgery. for anastomotic leakage (main outcome) the results were: - Low anterior resection: 9.8% (11 of 112 patients in Group A) compared with 7.5% (9 of 119 patients in Group B); Peto OR 1.45, 95% confidence interval (CI): 0.57 to 3.67 (non-significant); - Colonic surgery: 2.9% (Group A) compared with 1.6% (Group B); Peto OR 1.80, 95% CI: 0.68 to 4.75 ( non-significant); Overall anastomotic leakage: 6.2% (Group A) compared with 3.2% (Group B); Peto OR 2.03, 95% CI: 1.276 to 3.26 ( p= 0.003). for the secondary outcome of wound infection the result was: 7.4% (Group A) compared with 5.4% (Group B); Peto OR 1.46, 95% CI: 0.97 - to 2.18 (p= 0.07); Sensitivity analyses excluding studies with dubious randomisation, studies published as abstracts only, and studies involving children did not change the overall conclusionsAuthors' conclusions There is no convincing evidence that mechanical bowel preparation is associated with reduced rates of anastomotic leakage after elective colorectal surgery. On the contrary, there is evidence that this intervention may be associated with an increased rate of anastomotic leakage and wound complications. It is not possible to be conclusion on the latter issue because of the clinical heterogeneity of trial inclusion criteria, methodological inadequacies in trial (in particular, poor reporting of concealment and allocation), potential performance biases, and failure of intention-to-treat analyses. Nevertheless, the dogma that mechanical bowel preparation is necessary before elective colorectal surgery should be reconsidered.
Idioma Inglês
Data de publicação 2005-01-01
Publicado em Cochrane Database of Systematic Reviews. Hoboken: Wiley-liss, n. 1, 30 p., 2005.
ISSN 1469-493X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 30
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000232097000096
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