IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

Autor Sader, Helio Silva Autor UNIFESP Google Scholar
Reis, A. O. Autor UNIFESP Google Scholar
Silbert, Suzane Autor UNIFESP Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Instituição Jones Grp
Universidade Federal de São Paulo (UNIFESP)
Resumo Pseudomonas aeruginosa isolates (n = 183), collected from bacteraemic patients hospitalised in São Paulo Hospital (Brazil) during 2000-2001, were screened for susceptibility to antimicrobial agents. the polymyxins were the most active compounds (100% susceptibility), followed by amikacin and cefepime (59.0%), meropenem (57.4%), and imipenem and gentamicin (55.2%). Imipenem-resistant isolates were ribotyped and screened for production of metallo-beta-lactamases (MBLs) by PCR with primers for bla(IMP), bla(VIM) and bla(SPM). MBL production was detected in 36 isolates (19.7% of the entire collection; 43.9% of the imipenem-resistant isolates) and the MBLs included SPM-1-like (55.6%), VIM-2-like (30.6%) and IMP-1-like (8.3%) enzymes.
Palavra-chave carbapenem resistance
imipenem resistance
metallo-beta-lactamases
polymyxin
Pseudomonas aeruginosa
Idioma Inglês
Data de publicação 2005-01-01
Publicado em Clinical Microbiology and Infection. Oxford: Blackwell Publishing Ltd, v. 11, n. 1, p. 73-76, 2005.
ISSN 1198-743X (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Ltd
Extensão 73-76
Fonte http://dx.doi.org/10.1111/j.1469-0691.2004.01031.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000226345700015
Endereço permanente http://repositorio.unifesp.br/handle/11600/28057

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