Hyperventilation revisited: Physiological effects and efficacy on focal seizure activation in the era of video-EEG monitoring

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dc.contributor.author Guaranha, Mirian SB
dc.contributor.author Garzon, Eliana [UNIFESP]
dc.contributor.author Buchpiguel, Carlos A.
dc.contributor.author Tazima, Sergio
dc.contributor.author Yacubian, Elza MT [UNIFESP]
dc.contributor.author Sakamoto, Américo C. [UNIFESP]
dc.date.accessioned 2016-01-24T12:37:32Z
dc.date.available 2016-01-24T12:37:32Z
dc.date.issued 2005-01-01
dc.identifier http://dx.doi.org/10.1111/j.0013-9580.2005.11104.x
dc.identifier.citation Epilepsia. Malden: Blackwell Publishing Inc, v. 46, n. 1, p. 69-75, 2005.
dc.identifier.issn 0013-9580
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28056
dc.description.abstract Purpose: Hyperventilation is an activation method that provokes physiological slowing of brain rhythms, interictal discharges, and seizures, especially in generalized idiopathic epilepsies. in this study we assessed its effectiveness in inducing focal seizures during video-EEG monitoring.Methods: We analyzed the effects of hyperventilation (HV) during video-EEG monitoring (video-EEG) of patients with medically intractable focal epilepsies. We excluded children younger than 10 years, mentally retarded patients, and individuals with frequent seizures.Results: We analyzed 97 patients; 24 had positive seizure activation (PSA), and 73 had negative seizure activation (NSA). No differences were found between groups regarding sex, age, age at epilepsy onset, duration of epilepsy, frequency of seizures, and etiology. Temporal lobe epilepsies were significantly more activated than frontal lobe epilepsies. Spontaneous and activated seizures did not differ in terms of their clinical characteristics, and the activation did not affect the performance of ictal single-photon emission computed tomography (SPECT).Conclusions: HV is a safe and effective method of seizure activation during monitoring. It does not modify any of the characteristics of the seizures and allows the obtaining of valuable ictal SPECTs. This observation is clinically relevant and suggests the effectiveness and the potential of HV in shortening the presurgical evaluation, especially of temporal lobe epilepsy patients, consequently reducing its costs and increasing the number of candidates for epilepsy surgery. en
dc.format.extent 69-75
dc.language.iso eng
dc.publisher Blackwell Publishing Inc
dc.relation.ispartof Epilepsia
dc.rights Acesso aberto
dc.subject EEG en
dc.subject video-EEG en
dc.subject hyperventilation en
dc.subject seizure activation en
dc.subject monitoring en
dc.title Hyperventilation revisited: Physiological effects and efficacy on focal seizure activation in the era of video-EEG monitoring en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Nucl Med Lab, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Sch Med, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol, Escola Paulista Med, São Paulo, Brazil
dc.identifier.doi 10.1111/j.0013-9580.2005.11104.x
dc.description.source Web of Science
dc.identifier.wos WOS:000226810000009



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