Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians

Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians

Autor Cardone, JDB Google Scholar
Chiba, A. K. Google Scholar
Boturao-Neto, E. Google Scholar
Vieira, JPB Google Scholar
Bordin, J. O. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The HPA-15 (Gov) alloantigen is a biallelic co-dominant system on human platelets, and its allele HPA-15a and HPA-15b differ by an A-->C single nucleotide polymorphism at nucleotide 2108 of the coding sequence resulting in a Tyr682Ser substitution in the mature CD109 glycoprotein.Employing the polymerase chain reaction-restriction fragment length polymorphism technique, we determined the HPA-15 gene frequencies among 276 subjects of distinct Brazilian ethnic groups including, 15 Caucasians, 15 African Brazilians, 15 Orientals, 106 Amazon Xikrin Indians, 31 Amazon Gavioes Indians and 94 blood donors.The calculated HPA-15a and HPA-15b allele frequencies found in Caucasians (0.53/0.47), African Brazilians (0.57/0.43), Orientals (0.57/0.43) and Brazilian blood donors (0.52/0.48) did not differ significantly. However, the HPA-15a and HPA-15b gene frequencies of Xikrin Indians (0.78/0.22) were significantly different from that of all other groups (P < 0.01). the HPA-15a/a, HPA-15a/b and HPA-15b/b genotype frequencies observed in Gavioes Indians were significantly different from those seen in African Brazilians (P = 0.04) and blood donors (P = 0.017).The present data showed that the distribution of the HPA-15 (Gov) system alleles observed among the Brazilian population is quite similar to the distributions already reported among Asian, Canadian and European populations. Moreover, the data indicated differences in the frequency of the HPA-15 system between Amazon Indians and other distinct Brazilian ethnic groups suggesting that Amerindians would be at higher risk of HPA-15 alloimmunization in the need of receiving blood components collected from blood donors of other ethnic groups.
Palavra-chave alloimmunization
Amazon Indians
blood donors
platelet antigens
Idioma Inglês
Data de publicação 2004-12-01
Publicado em Transfusion Medicine. Oxford: Blackwell Publishing Ltd, v. 14, n. 6, p. 433-437, 2004.
ISSN 0958-7578 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Ltd
Extensão 433-437
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000225406200006
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