Role of anxiety levels in memory performance of spontaneously hypertensive rats

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dc.contributor.author Calzavara, M. B.
dc.contributor.author Lopez, G. B.
dc.contributor.author Abilio, V. C.
dc.contributor.author Silva, R. H.
dc.contributor.author Frussa, R.
dc.date.accessioned 2016-01-24T12:37:31Z
dc.date.available 2016-01-24T12:37:31Z
dc.date.issued 2004-12-01
dc.identifier http://dx.doi.org/10.1097/00008877-200412000-00003
dc.identifier.citation Behavioural Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 8, p. 545-553, 2004.
dc.identifier.issn 0955-8810
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28043
dc.description.abstract Spontaneously hypertensive rats (SHR) show behavioural differences when compared to their strain-matched controls. These differences include decreased anxiety-like behaviour in SHR, while both improved performance and behavioural deficits have been reported in learning/ memory studies. Considering that alterations in anxiety levels during the training session can modify retention performance in animal models of memory, the aim of the present study was to investigate the role of anxiety levels in the performance of SHR rats in the plus-maze discriminative avoidance task (PM-DAT), in which memory and anxiety are evaluated simultaneously. Adult (5-month-old) and young (45-day-old) SHR and normotensive Wistar rats (NWR) were treated with chlordiazepoxide (CDZ) or saline. Thirty minutes later, rats were submitted to the PM-DAT training session. After 24 h, the test session was performed. the results showed that: (1) adult SHR showed lower anxiety levels compared to adult NWR; (2) adult SHR and NWR, as well as young NWR, showed significant retention of the task, while young SHR showed impaired performance; (3) 5.0 mg/kg CDZ decreased anxiety levels in adult NWR and young and adult SHR; (4) 5.0 mg/kg CDZ impaired retention in adult SHR and NWR and increased retention in young SHR. Our data suggest an important role of anxiety levels in the performance of SHR in a plus-maze discriminative avoidance task. Behavioural Pharmacology 15:545-553 (C) 2004 Lippincott Williams Wilkins. en
dc.format.extent 545-553
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Behavioural Pharmacology
dc.rights Acesso restrito
dc.subject spontaneously hypertensive rats en
dc.subject chlordiazepoxide en
dc.subject anxiety en
dc.subject memory en
dc.subject plus maze en
dc.subject discriminative avoidance en
dc.title Role of anxiety levels in memory performance of spontaneously hypertensive rats en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1097/00008877-200412000-00003
dc.description.source Web of Science
dc.identifier.wos WOS:000226142000003



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