Exercise restores immune cell function in energy-restricted rats

Exercise restores immune cell function in energy-restricted rats

Autor Cunha, Wilton Darleans dos Santos Google Scholar
Giampietro, M. V. Google Scholar
Souza, D. F. de Google Scholar
Vaisberg, Mauro Autor UNIFESP Google Scholar
Seelaender, MCL Google Scholar
Rosa, LFBPC Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To evaluate the effect of chronic moderate-intensity exercise upon the alterations of immune system cell function induced by energy restriction.Methods: Forty male Wistar rats were randomly assigned to the following groups: sedentary animals fed ad libitum (SF, N = 10) or submitted to energy restriction (SER, N = 10, receiving 50% of the mean amount of chow consumed by SF); and trained animals fed ad libitum (TF, N = 10) or submitted to energy restriction (TER, N = 10), who exercised on a treadmill (at 60-65% VO2max) 5 d(.)wk(-1) for 10 wk, after 30 d under the restriction protocol. the incorporation of [2-C-14]-thymidine by lymphocytes obtained from the spleen and mesenteric lymph nodes, plasma glucose and glutamine concentration, and cytokine production by cells cultivated in the presence of glutamine were measured in all groups, 24 h after the last exercise session. Two-way ANOVA and Tukey's posttest were employed for the statistical analysis.Results: Training induced an increase in the proliferative response and in the production of gamma-interferon and interleukin-1 (P < 0.05) in cells from the spleen and lymph nodes of SER, in which these parameters were diminished when compared with SF (P < 0.05). SER spleen and lymph node cells produced more TNF (26 and 42%, respectively) and IL-2 (49 and 42%, respectively) than SF. the Th-1-like diversion of the immune response observed in SER persisted after training. Partial recovery of the decreased SER plasma glutamine concentration and muscle glutamine synthase mRNA was observed.Conclusions: Training induced the recovery of the proliferative capacity of lymphocytes from SER, probably due to the partial restoration of plasma glutamine levels, but did not interfere with the diversion towards a Th-1-type immune response induced by food restriction.
Palavra-chave training
malnourishment
cytokines
energy restriction
glutamine synthase
lymphocytes
Idioma Inglês
Data de publicação 2004-12-01
Publicado em Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 36, n. 12, p. 2059-2064, 2004.
ISSN 0195-9131 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 2059-2064
Fonte http://dx.doi.org/10.1249/01.MSS.0000147626.32295.38
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000225547500008
Endereço permanente http://repositorio.unifesp.br/handle/11600/28030

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