Perinatal salt restriction: A new pathway to programming insulin resistance and dyslipidemia in adult Wistar rats

Perinatal salt restriction: A new pathway to programming insulin resistance and dyslipidemia in adult Wistar rats

Autor Vidonho, Armando F. Google Scholar
Da Silva, Alexandre A. Google Scholar
Catanozi, Sergio Google Scholar
Rocha, Jussara C. Google Scholar
Beutel, Abram Autor UNIFESP Google Scholar
Carillo, Bruno de Arruda Autor UNIFESP Google Scholar
Furukawa, Luzia N Shinohara Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Carpinelli, Angelo R. Google Scholar
Quintão, Eder Carlos Rocha Autor UNIFESP Google Scholar
Dolnikoff, Miriam Sterman Autor UNIFESP Google Scholar
Heimann, Joel C. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Several studies support the hypothesis that chronic diseases in adulthood might be triggered by events that occur during fetal development. This study examined the consequences of perinatal salt intake on blood pressure (BP) and carbohydrate and lipid metabolism in adult offspring of dams on high-salt [HSD; 8% (HSD2) or 4% (HSD1)], normal-salt (NSD; 1.3%), or low-salt (LSD; 0.15% NaCl) diet during pregnancy and lactation. At 12 wk of age, female Wistar rats were matched with adult male rats that were fed NSD. Weekly tail-cuff BP measurements were performed before, during, and after pregnancy. After weaning, the offspring received only NSD and were housed in metabolic cages for 24-h urine collection for sodium and potassium and nitrate and nitrite excretion measurements. At 12 wk of age, intra-arterial mean BP was measured, a euglycemic-hyperinsulinemic clamp was performed, and plasma lipids and nitrate and nitrite concentrations were determined. Tail-cuff BP was higher during pregnancy in HSD2 and HSD1 than in NSD and LSD dams. Mean BP (mm Hg) was also higher in the offspring of HSD2 (110 +/- 5) and HSD1 (107 +/- 5) compared with NSD (100 +/- 2) and LSD (92 +/- 2). Lower glucose uptake and higher plasma cholesterol and triacylglycerols were observed in male offspring from LSD dams (glucose uptake: HSD2 17 +/- 4, HSD1 15 +/- 3, NSD 11 +/- 3. LSD 4 +/- 1 mg (.) kg(-1) min(-1); cholesterol: HSD2 62 +/- 6, HSD1 82 +/- 11, NSD 68 +/- 10, LSD 98 +/- 17 mg/dL; triacylglycerols: HSD2 47 +/- 15, HSDI 49 +/- 12, NSD 56 +/- 19, LSD 83 +/- 11 mg/dL). in conclusion, maternal salt intake during pregnancy and lactation has long-term influences on arterial pressure, insulin sensitivity, and plasma lipids of the adult offspring.
Idioma Inglês
Data 2004-12-01
Publicado em Pediatric Research. Baltimore: Int Pediatric Research Foundation, Inc, v. 56, n. 6, p. 842-848, 2004.
ISSN 0031-3998 (Sherpa/Romeo, fator de impacto)
Editor Int Pediatric Research Foundation, Inc
Extensão 842-848
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000225346700002

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