Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases

Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases

Autor Barros, NMT Google Scholar
Puzer, L. Google Scholar
Tersariol, ILS Google Scholar
Oliva, MLV Google Scholar
Sampaio, CAM Google Scholar
Carmona, A. K. Google Scholar
Motta, G. da Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UMC
Resumo Plasma kallikrein plays a role in coagulation, fibrinolysis and inflammation. Cathepsins B and L participate in (patho)physiological processes such as peptide antigen processing, tissue remodeling events, protein turnover in cells, hormone processing and tumor invasion. the present work analyzes the processing of prekallikrein/kallikrein by lysosomal cathepsins. Prekallikrein is not hydrolyzed by catB, and catL generates an inactive fragment of prekallikrein. Both kallikrein chains are hydrolyzed by catL and the light chain is mainly hydrolyzed by catB; kallikrein activity is lower after incubation with catL compared to catB. Our data suggest that the plasma kallikrein/kinin system can be controlled by cathepsins.
Palavra-chave cathepsins
kallikrein
kinin system
proteolysis
Idioma Inglês
Data de publicação 2004-11-01
Publicado em Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 385, n. 11, p. 1087-1091, 2004.
ISSN 1431-6730 (Sherpa/Romeo, fator de impacto)
Publicador Walter de Gruyter & Co
Extensão 1087-1091
Fonte http://dx.doi.org/10.1515/BC.2004.141
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000225438200014
Endereço permanente http://repositorio.unifesp.br/handle/11600/28019

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