Pharmacological study of Stachytarpheta cayennensis Vahl in rodents

Pharmacological study of Stachytarpheta cayennensis Vahl in rodents

Autor Mesia-Vela, S. Google Scholar
Souccar, C. Google Scholar
Lima-Landman, MTR Google Scholar
Lapa, A. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Freeze-dried aqueous extracts (AEs, 0.1-1 g/kg body wt., p.o.) obtained from entire or selected parts of Stachytarpheta cayennensis were tested for their effects on gastric secretion, gastric motility, inflammation and pain in rodents, with the purpose of validating the plant's ethnomedical uses. the AE-Total, AE-Flowers and AE-Leaves but not AE-Stems inhibited the gastric acid secretion in pylorus-ligated rats with varying potency. Purification of AEs yielded the semipurifed fractions EtFs rich in iridoids. All the EtFs with exception of EtF-Stems inhibited gastric acid secretion of pylorus ligated mice. While AE-Total stimulated the intestinal transit of mice by 43%, AE-eaves delayed it by 38%. These effects on intestinal transit were not observed when the EtFs were tested. Only AE-Leaves and AE-Flowers altered the gastric emptying of semisolids, increasing it by 45% and 69%, respectively. These results indicate that the compounds related to inhibition of gastric acid secretion and gastrointestinal motility are different. the AE-Total reduced abdominal writhing induced by acetic acid potently (ED50 value = 700 mg/kg, p.o.) without altering the writhes induced by acetylcholine. Attempts to identify the mechanism of analgesia were unsuccessful since the AETotal did not show analgesic effects when tested in different models of pain such as formalin and capsaicin or the tailflick test. Pretreatment of animals with AE-Total did not show antiinflammatory activity in any of the acute (paw edema induced by carrageenin, dextran or histamine, pleurisy induced by carrageenin and capsaicin-induced mouse ear edema) or chronic (air pouch) models used. No toxic signs were observed after administration of the different extracts up to 2 g/kg body wt., p.o.Collectively, the results confirmed folk information indicating presence of analgesic, mild laxative and potent inhibition of gastric secretion activities in the aqueous extracts of S. cayennensis. the results do not, however confirm the folk use of the plant as an antiinflammatory medicine. (C) 2004 Elsevier GmbH. All rights reserved.
Palavra-chave Stachytarpheta cayennensis
antiacid
antiulcer
gastric acid secretion
Idioma Inglês
Data de publicação 2004-11-01
Publicado em Phytomedicine. Jena: Urban & Fischer Verlag, v. 11, n. 7-8, p. 616-624, 2004.
ISSN 0944-7113 (Sherpa/Romeo, fator de impacto)
Publicador Urban & Fischer Verlag
Extensão 616-624
Fonte http://dx.doi.org/10.1016/j.phymed.2003.05.001
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000226315400008
Endereço permanente http://repositorio.unifesp.br/handle/11600/28011

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